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首页> 外文期刊>Advances in renal replacement therapy >Immunosuppressive drugs in pregnancy.
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Immunosuppressive drugs in pregnancy.

机译：怀孕期间的免疫抑制药物。

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摘要

Successful pregnancies are now common in female organ transplant recipients. Despite high rates of success, pregnancy in an organ transplant recipient should be managed as a high-risk condition with emphasis on prevention and prompt treatment of rejection episodes. The number of immunosuppressive drugs and drug combinations has increased in recent years. Data accrued by a national registry indicate that pregnancy is generally successful in patients maintained on some combination of cyclosporine, azathioprine, and steroids. Relatively little information is available regarding the safety of some of the newer immunosuppressive agents in pregnancy. Until additional information is collected, transplant physicians and obstetricians must balance the efficacy of immunosuppressants in preventing allograft rejection in the mother against possible adverse drug reactions in both the mother and fetus.
机译：现在，成功的怀孕在女性器官移植接受者中很普遍。尽管成功率很高，但应将器官移植接受者的妊娠作为高危疾病进行管理，重点在于预防和迅速治疗排斥反应。近年来，免疫抑制药物和药物组合的数量有所增加。国家注册机构获得的数据表明，使用环孢素，硫唑嘌呤和类固醇的某些组合维持的患者通常可以成功怀孕。关于某些新型免疫抑制剂在妊娠中的安全性的信息相对较少。在收集到更多信息之前，移植医师和妇产科医生必须权衡免疫抑制剂在预防母体同种异体移植排斥与母体和胎儿可能发生的不良药物反应之间的功效。

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