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首页> 外文期刊>Materials science & engineering, C. Materials for Biogical applications >Preparation of AIE-active fluorescent polymeric nanoparticles through a catalyst-free thiol-yne click reaction for bioimaging applications
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Preparation of AIE-active fluorescent polymeric nanoparticles through a catalyst-free thiol-yne click reaction for bioimaging applications

机译：通过催化剂 - 无活性荧光聚合物纳米粒子的制备通过催化剂 - 无催化剂 - YNE咔哒反应用于生物分析应用

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Abstract Fluorescent polymeric nanoparticles (FPNs) with aggregation-induced emission (AIE) characteristics have attracted much attention for biomedical applications due to their remarkable AIE feature, high water dispersity and desirable biocompatibility. The development of facile and effective strategies for fabrication of these AIE-active FPNs therefore should be of great importance for their biomedical applications. In this work, we reported that a catalyst-free thiol-yne click reaction can be utilized for fabrication of AIE-active FPNs in short reaction time and even without protection of inert gas. The results indicated that the obtained AIE-active amphiphilic copolymers (PEGMA-PhE) can readily self-assemble into luminescent nanoparticles (PEGMA-PhE FPNs) with high water dispersity, uniform size and morphology, red fluorescence. Cell viability examination and cell uptake behavior of PEGMA-PhE FPNs confirmed that these AIE-active FPNs possess low toxicity towards cells and can be easily internalized by cells through non-specific route. Therefore the remarkable properties of PEGMA-PhE FPNs such as high water dispersity, AIE-active fluorescence and nanoscale size as well as excellent biocompatibility make them promising for biomedical applications. Graphical abstract The
机译：<！[cdata [ 抽象 荧光聚合物纳米颗粒（FPNS）具有聚集诱导的发射（AIE）特性引起了较大的对生物医学应用的关注他们显着的AIE特征，高水分散性和理想的生物相容性。因此，对这些AIE活性FPN的制造方便和有效策略的发展应该非常重要地对其生物医学应用。在这项工作中，我们报道了一种无催化剂的硫醇-YNE点击反应可用于在短反应时间内制造AIE活性FPN，甚至不受惰性气体。结果表明，所获得的AIE-活性两亲共聚物（PEGMA-PHE）可以容易地将自组装成具有高水分散性，均匀的尺寸和形态，红色荧光的发光纳米颗粒（PEGMA-PHE FPN）。 PEGMA-PHE FPN的细胞活力检查和细胞吸收行为证实，这些AIE活性FPN对细胞具有低毒性，并且可以通过细胞通过非特定途径容易地内化。因此，PEGMA-PHE FPN的显着性质如高水分散性，AIE-活性荧光和纳米尺度以及优异的生物相容性使它们对生物医学应用有望。 图形摘要

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