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首页> 外文期刊>Materials science & engineering, C. Materials for Biogical applications >One step preparation of polymeric maltitol particles, from a sugar molecule, maltitol for biomedical applications
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One step preparation of polymeric maltitol particles, from a sugar molecule, maltitol for biomedical applications

机译：聚合物麦芽糖醇颗粒的一步制备，来自糖分子，麦芽糖醇用于生物医学应用

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摘要

Here, a facile method for the preparation of polymeric particles from a sugar molecule, maltitol (ML) in single step was reported via microemulsion polymerization/crosslinking technique with a high yield, 89 +/- 6%. Furthermore, poly(Maltitol) (p(ML)) particles were chemically modified to induce different physicochemical characteristic using different anionic and cationic modifying agents such as taurine (TA) and diethylenetriamine (DETA) to prepare m-p(ML)/TA and m-p(ML)/DETA. The blood compatibility of the p(ML) particles and their modified forms were tested with fresh blood, and found that p(ML) and m-(ML)/DETA particles are blood compatible with about 5% hemolysis, and above 80% blood clotting indices. Moreover, the cytotoxicity results against L929 fibroblast cell line revealed that p(ML) based particle are biocompatible up to 100 mu g/mL with 85% cell viability regardless of their nature, and at 200 mu g/mL dosage of p(ML), m-p(ML)/TA and m-p(ML)/DETA particles, the cell viabilities were determined as 83.33, 64.03 and 73.89% on for L929 fibroblast cells implying the slightly less biocompatibility nature of m-p(ML)/TA in accord with the blood compatibility results. Additionally, the apoptotic and necrotic indices were determination for p(ML) based particles on L929 fibroblast cells, and the results revealed that these particles do not induce any and stress on the cells. Also, it does not have genotoxic effect as determined against CHO cells.
机译：这里，通过高产率高，89 +/- 6％的微乳液聚合/交联技术报道，在单步中制备来自糖分子的聚合物颗粒的化合物颗粒的容易方法。此外，聚（马耳他）（p（ml））颗粒化学修饰以使用不同的阴离子和阳离子改性剂如牛磺酸（ta）和二亚乙基三胺（DETA）来诱导不同的物理化学特性，得到MP（mL）/ TA和MP（ ml）/ deta。用新鲜血液测试p（ml）颗粒及其改性形式的血液相容性，发现p（ml）和m-（ml）/滴度颗粒与约5％的溶血，80％血液相容凝结指数。此外，针对L929成纤维细胞系的细胞毒性结果显示，无论其性质如何，P（mL）基于基于P（ml）的颗粒高达100μg/ ml，其性质，并且在200μmg/ ml的p（ml）的用量，MP（mL）/ TA和MP（mL）/滴度颗粒，细胞活力被确定为L929成纤维细胞的83.33,64.03和73.89％，暗示MP（mL）/ TA的略微不相容性性质血液兼容性结果。另外，凋亡和坏死指数是在L929成纤维细胞上基于p（ml）颗粒的测定，结果显示这些颗粒不会诱导细胞上的任何和应激。此外，它没有针对CHO细胞确定的基因毒性效应。

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