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The use of deep brain stimulation in Tourette's syndrome

机译：在Tourette综合征中使用深脑刺激

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Tourette's syndrome (TS) is a childhood neuropsychiatric disorder characterized by multiple involuntary motor and vocal tics. It is commonly associated with other behavioral disorders including attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, anxiety, depression, and self-injurious behaviors. Tourette's syndrome can be effectively managed with psychobehavioral and pharmacological treatments, and many patients experience an improvement in tics in adulthood. However, symptoms may persist and cause severe impairment in a small subset of patients despite available therapies. In recent years, deep brain stimulation (DBS) has been shown to be a promising treatment option for such patients. Since the advent of its use in 1999, multiple targets have been identified in DBS for TS, including the medial thalamus, globus pallidus internus, globus pallidus externus, anterior limb of the internal capsule/nucleus accumbens, and subthalamic nucleus. While the medial thalamus is the most commonly reported trajectory, the optimal surgical target for TS is still a topic of much debate. This paper provides a review of the available literature regarding the use of DBS for TS.
机译：Tourette的综合症（TS）是一种儿童的神经精神障碍，其特征是多重的非自愿电机和声带。它通常与其他行为障碍有关，包括注意力缺陷/多动障碍，强迫症，焦虑，抑郁和自我伤害行为。 Tourette的综合征可以通过精神言语和药理治疗有效地管理，许多患者在成年期间经历了改良的TICS。然而，尽管有可用的疗法，症状可能持续和造成严重损害。近年来，深脑刺激（DBS）已被证明是此类患者的有希望的治疗选择。自1999年使用的出现以来，在DBS的DBS中鉴定了多种目标，包括内侧丘脑，GlobusPallidus Internus，Globus Pallidus externus，内囊腔内的前肢，和亚粒细胞核。虽然内侧丘脑是最常见的轨迹，但TS的最佳手术目标仍然是一个很多争论的主题。本文介绍了关于使用DBS的可用文献。

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