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首页> 外文期刊>Nutrition >Beneficial effects of Lactobacillus plantarum on glycemia and homocysteine levels in postmenopausal women with metabolic syndrome
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Beneficial effects of Lactobacillus plantarum on glycemia and homocysteine levels in postmenopausal women with metabolic syndrome

机译：乳酸杆菌对后代综合征绝经后妇女血糖和同型血清水平的益处

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Objective: Metabolic syndrome (MetS) in postmenopausal women is an important risk factor for cardiovascular morbidity, especially stroke and coronary heart disease and mortality. Preventing and treating MetS would be useful in preventing disability and promoting normal aging. Previous human studies have found some beneficial effects of Lactobacillus species on some isolated parameters of MetS. Nevertheless, we are not aware, to date, of any study which has verified the influence of probiotics in patients with MetS. Therefore, the aim of the present study was to evaluate the influence of fermented milk with L. plantarum in the classical parameters related to MetS, as well as in other parameters related to cardiovascular risk in postmenopausal women. Methods: Twenty-four individuals were paired by age, ethnicity, and body mass index in two groups: Non-fermented milk (NFM=12) 80mL/d and fermented milk (FM=12) 80mL/d. Anthropometric and blood pressure measurements, biochemical, inflammatory, and immunologic biomarkers were measured. Results: Total cholesterol and γ-glutamyltranspeptidase had a significant reduction both in NFM (P=0.043 and P=0.036, respectively) and FM groups (P=0.010 and P=0.018, respectively) after 90d, whereas low-density lipoprotein cholesterol showed a significant reduction in NFM group (P=0.002) and trend in the FM group (P=0.092). Glucose and homocysteine levels showed a significant reduction in the FM group compared with the NFM group (P=0.037 and P=0.019, respectively). In relation to inflammatory biomarkers, there was a significant decrease in interleukin-6 both in NFM (P=0.032) and in FM (P=0.001) groups. Conclusion: FM with L. plantarum showed more favorable results than NFM in relation to cardiovascular risk factors in postmenopausal women with MetS.
机译：目的：绝经后妇女的代谢综合征（Mets）是心血管发病率的重要风险因素，尤其是中风和冠心病和死亡率。预防和治疗MET可用于预防残疾和促进正常衰老。以前的人类研究发现乳酸杆菌物种对Mets的一些分离参数的一些有益作用。尽管如此，我们并不知道迄今为止核实益生菌对MET患者的影响。因此，本研究的目的是评估发酵牛奶在与Mets相关的经典参数中与L.Plantarum的影响，以及与绝经后妇女的心血管风险相关的其他参数。方法：二十四个人按年龄，种族和体重指数分配两组：非发酵牛奶（NFM = 12）80ml / D和发酵牛奶（FM = 12）80ml / d。测量人体测量和血压测量，生化，炎症和免疫生物标志物。结果：总胆固醇和γ-谷氨酸转肽酶在90D后（P = 0.043和P = 0.036分别）和FM基团（分别分别为0.010和P = 0.018），而低密度脂蛋白胆固醇显示出来NFM组（P = 0.002）的显着降低和FM组的趋势（P = 0.092）。与NFM组相比，葡萄糖和同型半胱氨酸水平显示FM组的显着降低（P = 0.037和P = 0.019）。与炎性生物标志物相关，在NFM（P = 0.032）和FM（P = 0.001）组中，白细胞介素-6的显着降低。结论：与Metsal Mets的绝经后妇女的心血管危险因素相关，Plantarum的FM比NFM更有利。

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