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Glucocorticoids in pregnancy

机译:怀孕的糖皮质激素

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The physiological changes that occur during pregnancy include altered regulation of the hypothalamo-pituitary-adrenal axis. The fetoplacental unit plays a major role in this, together with alteration of circulating cortisol-binding globulin levels, with a net effect to increase both total and free cortisol levels. Importantly, there are several pathological conditions that require steroid treatment or replacement during pregnancy, and optimizing therapy is clearly crucial. The potential for acute and chronic adverse effects that can impact upon both the mother and the fetus makes the decision of how and when to instigate steroid therapy particularly challenging. In this review, we describe the physio-pathological changes to the hypothalamo-pituitary-adrenal axis that occur during pregnancy, tools to assess endogenous glucocorticoid reserve as well as discuss treatment strategies and the potential for the development of adverse events.
机译:妊娠期间发生的生理变化包括改变下丘脑 - 垂体 - 肾上腺轴的调节。 胎足工学单元在这方面发挥了重要作用,以及循环皮质醇结合球蛋白水平的改变,净效应增加了总和游离的皮质醇水平。 重要的是,有几种病理条件需要在怀孕期间需要类固醇治疗或替代品,并且优化治疗显然至关重要。 可能对母亲和胎儿产生影响的急性和慢性不利影响的可能性是如何以及何时促进类固醇疗法特别具有挑战性的决定。 在本综述中,我们描述了在妊娠期间发生的下丘脑 - 垂体 - 肾上腺轴的生理病理变化,评估内源性糖皮质激素储备的工具以及讨论治疗策略以及潜在的发展不良事件的潜力。

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