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首页> 外文期刊>Ocular oncology and pathology. >Uveal Melanoma in Ireland
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Uveal Melanoma in Ireland

机译:无用的黑色素瘤在爱尔兰

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Purpose: To report the clinical features and epidemiology of uveal melanoma in Ireland. Methods: This was an observational study of 253 patients with a new diagnosis of uveal melanoma between June 2010 and December 2015. Main outcome measures included demographics, clinical features, age-adjusted incidence, relative survival, overall survival, and distant metastases-free survival. Results: The mean patient age was 61.7 years. Tumour location was choroidal in 82%, ciliochoroidal in 9%, iridociliary in 2%, and iris in 7%. Treatment modalities included brachytherapy (ruthenium-106 and iodine-125 [64%]), enucleation (27%), and proton beam radiation (8%). The mean age-adjusted incidence of uveal melanoma in Ireland from 2010 to 2015 was 9.5 per million of the population (95% confidence interval [CI]: 8.4–10.7). Four-year relative survival was 81.3% (95% CI: 72.8–87.3). Four-year overall survival was 84% (95% CI: 78–90) and 4-year distant metastases-free survival was 79% (95% CI: 73–86). Conclusion: Based on this data, the incidence of uveal melanoma in Ireland is high when compared with other reported incidence rates in Europe and worldwide. Relative and observed survival were in keeping with other reported European survival rates.
机译:目的:报告爱尔兰过度黑素瘤的临床特征和流行病学。方法:这是2010年6月至2015年12月在2010年6月至12月之间进行了253名患有新诊断的患者的观察研究。主要的结果措施包括人口统计学,临床特征,年龄调整的发病率,相对生存,整体生存和远处转移。结果:平均患者年龄为61.7岁。肿瘤位置在82%的脉络膜中,9%,铱素,2%的铱,虹膜为7%。治疗方式包括近距离放射治疗(Ruthenium-106和碘-125 [64%]),enucleation(27%)和质子束辐射(8%)。 2010年至2015年爱尔兰Uveal黑色素瘤的平均年龄调整后发病率为9.5%百万人口(95%置信区间[CI]:8.4-10.7)。四年的相对生存率为81.3%(95%CI:72.8-87.3)。为期4年的总生存率为84%(95%CI:78-90),4年的远程转移存活率为79%(95%CI:73-86)。结论:根据这种数据,与欧洲和全球其他报告的发病率相比,爱尔兰的黑素瘤的发生率很高。相对和观察的生存率与其他报告的欧洲生存率保持着。

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