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首页> 外文期刊>Oral oncology >Health related quality of life in head and neck cancer treated with radiation therapy with or without chemotherapy: a systematic review.
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Health related quality of life in head and neck cancer treated with radiation therapy with or without chemotherapy: a systematic review.

机译：健康相关质量在头部和颈部癌症中用或无化疗的放射治疗治疗：系统评价。

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摘要

Health-related quality of life (HRQoL) is a subjective measure of patients' experience of disease and treatment. We systematically reviewed the literature to identify high quality manuscripts reporting HRQoL outcomes in adults with squamous cell carcinoma of the head and neck (HNSCC) treated with an organ-sparing curative regimen of radiation therapy with or without chemotherapy. Assessments were performed independently by two reviewers; a third reviewer resolved disputes. High quality reports were reviewed in detail to identify trends in HRQoL outcomes. MEDLINE and EMBASE searching yielded 276 distinct reports, plus 24 added via hand search. Of these, 53 met eligibility criteria and 18 were deemed high quality reports on the basis of a quality assessment tool. HRQoL declines after treatment but recovers to baseline levels, generally within 12months. However, xerostomia-related HRQoL deficits may remain long-term. Combined chemoradiotherapy showed a trend toward worse HRQoL compared with RT alone. Intensity modulated radiotherapy (IMRT) yields better HRQoL compared with conventional or three-dimensional conformal radiotherapy. Baseline HRQoL may independently predict local-regional control and overall survival. Future research should incorporate HRQoL into phase III trials. However, adequate effort and journal space must be afforded to the HRQoL results of these studies to ensure proper reporting methods are followed, allowing clinicians to incorporate HRQoL into patient counseling and clinical decision making.
机译：与健康有关的生活质量（HRQOL）是患者疾病和治疗经验的主观衡量标准。我们系统地审查了文献，以识别在成人中报告HRQOL结果的高质量手稿，其中用有或没有化疗的器官滥本治疗的器官滥本治疗治疗的头部和颈部（HNSCC）的鳞状细胞癌。评估由两名审稿人独立进行;第三次评论员解决了争议。详细审查了高质量的报告，以确定HRQOL结果的趋势。 Medline和Embase Searching产生了276个不同的报告，并通过手搜索添加24。其中，53次符合资格标准和18次以质量评估工具视为高质量报告。 HRQOL在治疗后下降，但恢复到基线水平，通常在12个月内。然而，Xerostomia相关的HRQOL缺陷可能保持长期。合并的化学疗法表明，与单独的RT相比，HRQOL的趋势表现出更差。与常规或三维保形放疗相比，强度调制放射疗法（IMRT）产生更好的HRQOL。基线HRQOL可以独立预测局部区域控制和整体生存。未来的研究应将HRQOL纳入第III期试验。然而，必须为这些研究的HRQOL结果提供充分的努力和期刊空间，以确保遵循正确的报告方法，允许临床医生将HRQOL纳入患者咨询和临床决策。

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