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首页> 外文期刊>Skin research and technology: official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) >Ex vivo full‐field cellular‐resolution optical coherence tomography of basal cell carcinomas: A pilot study of quality and feasibility of images and diagnostic accuracy in subtypes
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Ex vivo full‐field cellular‐resolution optical coherence tomography of basal cell carcinomas: A pilot study of quality and feasibility of images and diagnostic accuracy in subtypes

机译：基础细胞癌的前体内全场蜂窝分辨率光学相干性断层扫描：一种试验研究，对图像的图像质量和可行性以及亚型的诊断准确性

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Abstract Background Studies have reported the application of conventional optical coherence tomography (OCT) in the diagnosis of basal cell carcinoma (BCC). The new OCT provides cellular details similar to those in pathology slides and may reduce user learning time. This study aimed to demonstrate the quality of ex vivo full‐field cellular‐resolution OCT images and compare the diagnostic accuracy between physicians with varying pathology experience. Materials and Methods Sixty histologically confirmed BCCs were selected. Tissue samples were sectioned and scanned using OCT, and their features were compared with those of hematoxylin and eosin (H&E)‐stained sections. Thirty images were selected for the test administered to dermatology residents, dermatopathology fellows, and board‐certified general pathologists without any OCT experience. The pretest learning included a 3‐min instruction and 10‐min self‐study of four BCC variants. Results Histopathological BCC and normal histological features were clearly recognizable on the OCT images. The pathological BCC features observed in the OCT images correlated with those found in the H&E‐stained sections. Seven participants completed the test. The correct answer rates of the residents, fellows, and pathologists were 71%, 68%, and 83% for BCC and 44%, 57%, and 57% for the BCC subtypes, respectively. Conclusion All the participants identified BCC in 70% cases with a learning time of only 13?minutes. The results indicated that cellular‐resolution OCT provided high‐quality images similar to the conventional pathology slides. Pathology experience did reflect the diagnostic accuracy. However, a longer training time is still needed at all levels to recognize the BCC subtypes correctly.
机译：摘要背景研究报道了常规光学相干断层扫描（OCT）在基底细胞癌（BCC）的诊断中的应用。新的OCT提供类似于病理幻灯片的蜂窝细节，并且可以减少用户学习时间。本研究旨在展示前体内全场蜂窝分辨率 - 分辨率OCT图像的质量，并比较具有不同病理经验的医生之间的诊断准确性。材料和方法选择60个组织学证实的BCC。通过OCT分离和扫描组织样品，将它们的特征与苏木精和曙红（H＆amp; e）染色部分进行比较。选择施用皮肤科居民，皮肤病病理学家和董事会认证的一般病理学家的测试，没有任何OCT经验，选择了三十种图像。预测试的学习包括三分之一的指令和四个BCC变体的10分钟自学。结果在OCT图像上显然可识别组织病理学BCC和正常的组织学特征。在OCT图像中观察到的病理BCC特征与H＆amp中发现的那些相关的特征。电子染色部分。七位参与者完成了测试。居民，研究员和病理学家的正确答案率为71％，68％和83％，分别为BCC亚型的44％，57％和57％。结论所有参与者在＆gt中确定了BCC; 70％的学习时间仅为13？分钟。结果表明，蜂窝分辨率100元提供了类似于常规病理学幻灯片的高质量图像。病理经验确实反映了诊断准确性。但是，各级仍需要更长的培训时间来正确识别BCC亚型。

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