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A case of multicentric reticulohistiocytosis

机译：多中心术术的病例

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Multicentric reticulohistiocytosis (MRH) is a rare non-Langerhans histiocytosis of unknown etiology with a predilection for joint and skin. The characteristic clinical features are papulonodular skin eruptions and inflammatory polyarthritis, sometimes progressive to arthritis mutilans, a severe destructive arthropathy. Although these manifestations can present at the same time, it is more common that one feature precedes the others. Notably, these features are similar to those found in some rheumatic diseases, such as rheumatoid arthritis or dermatomyositis, and this can lead to a misdiagnosis, especially during periods where only one feature is present. Herein, we report a female patient with polyarthralgia and subsequent skin eruptions, who was eventually diagnosed with MRH. Her symptoms seemed to resemble those of some rheumatic diseases, but several features such as affected joints and the characteristic shape of the skin lesions did not correspond to that. The histological result of infiltration of histiocytes and multinucleated giant cells in the skin ultimately facilitated the correct diagnosis.
机译：多中心纹状体吞噬症（MRH）是一种罕见的非朗格汉斯组织菌，未知病因的未知病因，偏好对关节和皮肤。特征临床特征是幼儿胚胎皮肤喷发和炎症多关节炎，有时对关节炎比较的炎症性关节炎，严重的破坏性关节病。虽然这些表现形式可以同时出现，但更常见的是一个特征在其他功能之前。值得注意的是，这些特征类似于一些风湿性疾病（例如类风湿性关节炎或皮肤病）中发现的特征，这可能导致误诊，特别是在仅存在一个特征的时期期间。在此，我们报告具有多次曲线痛和随后的皮肤喷发的女性患者，最终被诊断为MRH。她的症状似乎类似于一些风湿性疾病，但是诸如受影响的关节和皮肤病变的特征形状等若干特征与此不符。皮肤中组织细胞和多核巨细胞渗透的组织学结果最终促进了正确的诊断。

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