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Haematophagic Caenorhabditis elegans

机译：血红蛋白Caenorhabditis elegans

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Caenorhabditis elegans is a free-living nematode that resides in soil and typically feeds on bacteria. We postulate that haematophagic C. elegans could provide a model to evaluate vaccine responses to intestinal proteins from hematophagous nematode parasites, such as Necator americanus. Human erythrocytes, fluorescently labelled with tetramethylrhodamine succinimidyl ester, demonstrated a stable bright emission and facilitated visualization of feeding events with fluorescent microscopy. C. elegans were observed feeding on erythrocytes and were shown to rupture red blood cells upon capture to release and ingest their contents. In addition, C. elegans survived equally on a diet of erythrocytes. There was no statistically significant difference in survival when compared with a diet of Escherichia coli OP50. The enzymes responsible for the digestion and detoxification of haem and haemoglobin, which are key components of the hookworm vaccine, were found in the C. elegans intestine. These findings support our postulate that free-living nematodes could provide a model for the assessment of neutralizing antibodies to current and future hematophagous parasite vaccine candidates.
机译：CaenorhabditiseDeltbiss是一种居住在土壤中的自由活的线虫，通常对细菌喂食。我们假设嗜血棒C.杆状杆菌可以提供一种评估疫苗对肠道蛋白质的疫苗反应，例如来自嗜血虫寄生虫，例如保险。用四甲基吡啶胺琥珀酰亚胺酯荧光标记的人红细胞，证明了荧光显微镜的稳定发射和促进饲养事件的可视化。观察到杆状杆菌，在红细胞上喂养，并被证明在捕获后破裂红细胞以释放并摄取其内容物。此外，C.杆骨杆菌同等地幸存下红细胞饮食。与大肠杆菌OP50的饮食相比，存活率没有统计学上显着的差异。在C.秀丽隐杆线虫肠道中发现了负责血红蛋白和血红蛋白的消化和血红蛋白的消化和解毒的酶。这些调查结果支持我们的假设，自由生活线虫可以提供评估对当前和未来血液寄生虫疫苗候选者的中和抗体的模型。

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