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首页> 外文期刊>Parasitology >Detection of persistent Plasmodium spp. infections in Ugandan children after artemether-lumefantrine treatment.
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Detection of persistent Plasmodium spp. infections in Ugandan children after artemether-lumefantrine treatment.

机译：检测持续疟原虫SPP。 乌干达儿童蒿甲菌儿童治疗后感染。

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摘要

During a longitudinal study investigating the dynamics of malaria in Ugandan lakeshore communities, a consistently high malaria prevalence was observed in young children despite regular treatment. To explore the short-term performance of artemether-lumefantrine (AL), a pilot investigation into parasite carriage after treatment(s) was conducted in Bukoba village. A total of 163 children (aged 2-7 years) with a positive blood film and rapid antigen test were treated with AL; only 8.7% of these had elevated axillary temperatures. On day 7 and then on day 17, 40 children (26.3%) and 33 (22.3%) were positive by microscopy, respectively. Real-time PCR analysis demonstrated that multi-species Plasmodium infections were common at baseline, with 41.1% of children positive for Plasmodium falciparum/Plasmodium malariae, 9.2% for P. falciparum/ Plasmodium ovale spp. and 8.0% for all three species. Moreover, on day 17, 39.9% of children infected with falciparum malaria at baseline were again positive for the same species, and 9.2% of those infected with P. malariae at baseline were positive for P. malariae. Here, chronic multi-species malaria infections persisted in children after AL treatment(s). Better point-of-care diagnostics for non-falciparum infections are needed, as well as further investigation of AL performance in asymptomatic individuals.
机译：在纵向研究期间，在乌干达湖岸社区的疟疾动态期间，尽管经常治疗，幼儿在幼儿中观察到始终如一的高疟疾患病率。为了探讨蒿甲醚 - Lumefantrine（Al）的短期表现，在治疗后对寄生虫携带的试验调查在Bukoba村进行。共有163名儿童（年龄2 - 7岁），用Al处理血膜和快速抗原试验;只有8.7％的腋下温度升高。在第7天，然后在第17天，40名儿童（26.3％）和33（22.3％）分别是显​​微镜的阳性。实时PCR分析表明，多物种疟原虫感染在基线时常见，41.1％的儿童对疟原虫/疟原虫疟原虫阳性阳性，P.Malciparum /疟原虫卵子SPP的9.2％。所有三种物种的8.0％。此外，在第17天，在基线中感染的39.9％的儿童患有疟疾疟疾的儿童再次为相同的物种阳性，9.2％的感染疟疾在基线中的疟疾呈阳性。在这里，慢性多种疟疾感染在Al治疗后持续存在于儿童。需要更好的非男性感染的护理点诊断，以及进一步调查无症状的人类的AL性能。

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