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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline
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Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline

机译：米诺霉素对学习的无助性大鼠产生抗抑郁症状的效果，随着杏仁达拉的单胺水平的改变，并且基线中海马的BDNF水平没有变化

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摘要

Previous studies have indicated that minocycline might function as an antidepressant drug. The aim of this study was to evaluate the antidepressant-like effects of minocycline, which is known to suppress activated microglia, using learned helplessness (LH) rats (an animal model of depression). Infusion of minocycline into the cerebral ventricle of LH rats induced antidepressant-like effects. However, infusion of minocycline into the cerebral ventricle of na?ve rats did not produce locomotor activation in the open field tests, suggesting that the antidepressant-like effects of minocycline were not attributed to the enhanced locomotion. LH rats showed significantly higher serotonin turnover in the orbitofrontal cortex and lower levels of brain-derived neurotrophic factor (BDNF) in the hippocampus than control rats. However, these alterations in serotonin turnover and BDNF expression remained unchanged after treatment with minocycline. On the contrary, minocycline treatment of LH rats induced significant increases in the levels of dopamine and its metabolites in the amygdala when compared with untreated LH rats. Taken together, minocycline may be a therapeutic drug for the treatment of depression.
机译：以前的研究表明，米诺环素可以用作抗抑郁药物。本研究的目的是评估米诺环素的抗抑郁药物，这已知已知抑制活性的微胶质细胞，使用学习的无助（LH）大鼠（抑郁的动物模型）。将米诺环素输注到LH大鼠诱导抗抑郁效果的脑室。然而，将米诺环素输注到Na'Ve大鼠的脑室中未在开放场测试中产生运动活化，表明米诺环素的抗抑郁效果不会归因于增强的运动。 LH大鼠在海马中胰腺癌皮质和脑源性神经营养因子（BDNF）中的血清素周转显着高于对照大鼠。然而，在用米诺环素治疗后，血清素周转和BDNF表达的这些改变保持不变。相反，与未处理的LH大鼠相比，LH大鼠对LH大鼠的百分比治疗诱导杏仁醛的二巴胺水平增加及其代谢物。一起携带，米诺环素可能是治疗抑郁症的治疗药物。

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    ArakawaS.; ShirayamaY.; FujitaY.; IshimaT.; HorioM.; MuneokaK.; IyoM.; HashimotoK.;

  • 作者单位

    Department of Psychiatry Chiba University Graduate School of Medicine 1-8-1 Inohana Chiba 260;

    Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health 1-8-1;

    Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health 1-8-1;

    Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health 1-8-1;

    Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health 1-8-1;

    Department of Psychiatry Chiba University Graduate School of Medicine 1-8-1 Inohana Chiba 260;

    Department of Psychiatry Chiba University Graduate School of Medicine 1-8-1 Inohana Chiba 260;

    Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health 1-8-1;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    BDNF; Depression; Learned helplessness (LH); Minocycline; Monoamines;

    机译：BDNF;抑郁症;学习无助（LH）;米诺霉素;单胺;

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