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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Tolerance to cocaine's effects on schedule-controlled behavior: Role of delay between pause-ending responses and reinforcement
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Tolerance to cocaine's effects on schedule-controlled behavior: Role of delay between pause-ending responses and reinforcement

机译：可卡因对日程控制行为的影响：暂停结束响应与加强之间的延迟作用

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The schedule of reinforcement under which behavior is maintained is an important contributor to whether tolerance to the behavioral effects of cocaine develops. Schedule parameter value (for example, fixed-ratio size) has been shown to affect the development of tolerance under some schedule types but not others, but the specific procedural variables causing this effect remain to be identified. To date, schedule-parameter-related tolerance has developed when a longer pause after reinforcement does not lead to a shorter delay between the response that ends the pause and reinforcement. The current study investigated the importance of this variable in pigeons using a multiple chained Fixed-Ratio 1, Fixed-Time x schedule, in which the first key peck in a trial produced a stimulus change and initiated a delay at the end of which food was presented regardless of whether or not additional pecks were made during the delay. Dose-response curves were assessed before, during and after chronic (daily) administration of cocaine. Tolerance to the pause-increasing effects of cocaine occurred to a similar degree regardless of the scheduled time between the end of the pause and reinforcement. Therefore, the relationship between pause length and delay to reinforcement does not provide an explanation for schedule-parameter-related tolerance.
机译：维持行为的加强时间表是对可卡因的行为影响的耐受性的重要贡献。计划参数值（例如，固定比率大小）已经显示为在某些时分类型下影响公差的发展，而不是其他方案，但仍然识别出现这种效果的具体程序变量。迄今为止，当加固后不会导致终止暂停和加固之间的响应之间的延迟更长的延迟时，将开发了与日程参数相关的公差。目前的研究研究了使用多链固定比率1，固定时间x时间表的鸽子在鸽子中的重要性，其中试验中的第一个关键啄食刺激改变并在哪个食物结束时发起延迟无论在延迟期间是否在延迟期间进行了额外的啄食。在慢性（每日）施用可卡因之前，期间和之后评估剂量 - 反应曲线。无论暂停和加固结束之间的预定时间如何，可卡因的暂停效果的耐受性越来越多。因此，暂停长度与增强件之间的关系不提供与日程参数相关的公差的解释。

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