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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of intraplantar Nocistatin and (±)-J 113397 injections on nociceptive behavior in a rat model of inflammation
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Effects of intraplantar Nocistatin and (±)-J 113397 injections on nociceptive behavior in a rat model of inflammation

机译：颅内甘露特汀和（±）-J113397对炎症大鼠益智模型中伤害性行为的影响

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摘要

Nocistatin (NST) and Nociceptin/Orphanin FQ (N/OFQ) are derived from the same precursor protein, pre-proN/OFQ, and exert opposite effects on the modulation of pain signals. However, the role of the peripheral N/OFQ and the NOP receptor, which is located at the endings of sensory nerves, in inflammatory pain was not ascertained. NST administered intrathecally (i.t.) prevented the nociceptive effects induced by i.t. N/OFQ and PGE 2. Moreover an up regulation of N/OFQ was shown in the rat in response to peripheral inflammation. Here, we investigated the effects of intraplantar (i.pl.) administration of functional N/OFQ and NOP receptor antagonists in a rat model of inflammatory pain. Our findings showed that i.pl. injection of (±)-J 113397, a selective antagonist of the NOP receptor, and NST, the functional N/OFQ antagonist, prior to carrageenan significantly reduced the paw allodynic and thermal hyperalgesic threshold induced by the inflammatory agent. The resulting antiallodynic and antihyperalgesic effects by co-administering NST and (±)-J 113397 prior to carrageenan were markedly enhanced, and the basal latencies were restored. Thus, it is likely that the peripheral N/OFQ/NOP receptor system contributes to the abnormal pain sensitivity in an inflammatory state.
机译：Nocistatin（NST）和Nociceptin /孤儿林FQ（N / OFQ）衍生自相同的前体蛋白质，预先发作/ OFQ，并对疼痛信号的调节产生相反的影响。然而，不确定外周N / OFQ和NOP受体位于感觉神经的结束的NOP受体的作用。 NST鞘内施用（即）阻止了I.T.诱导的伤害效应。 N / OFQ和PGE 2。此外，在大鼠中显示出N / OFQ的调节，响应外周炎症。在这里，我们研究了脑内植物植物（I.PL.）施用功能性N / Q和NOP受体拮抗剂在炎症疼痛的大鼠模型中的影响。我们的研究结果表明我是普利。在角叉菜胶之前，注射（±）-J11397，NOP受体的选择性拮抗剂和NST，功能性n / ofq拮抗剂，显着降低了由炎性剂诱导的爪子分解和热痛觉者阈值。通过共同施用NST和（±）-J113397在角叉菜胶之前得到的抗衰弱性和抗震术效应显着提高，并且基础延迟恢复。因此，外周N / OFQ / NOP受体系统可能有助于炎症状态的异常疼痛敏感性。

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