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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats
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Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats

机译：慢性二氟甲基胺治疗损害了大鼠的空间学习和记忆

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Recent evidence suggests that polyamines putrescine, spermidine and spermine are essential in maintaining normal cellular function. The present study investigated the effects of chronic treatment of difluoromethylornithine (DFMO, 3% in drinking water), a potent inhibitor of putrescine synthesis, for 54 consecutive days on animals'behavior and neurochemical levels in the CA1, CA2/3 and dentate gyrus sub-regions of the hippocampus and the prefrontal cortex. The DFMO group showed performance impairments in the place navigation and the probe test conducted 24 h after the training in the reference memory version of the water maze task, but not in the elevated plus maze, open field, object recognition, cued navigation and the working memory version of the water maze task when compared to the control group (drinking water only). DFMO treatment resulted in approximately 80-90% and 20% of reductions in the putrescine and spermidine levels, respectively, in the four brain regions examined, and a small reduction in agmatine level in the CA2/3, with no effects on spermine, glutamate and γ-aminobutyrate. The DFMO group showed decreased body weight relative to the control one. However, there were no significant differences between groups in the normalized brain, kidney and liver weights. The present study demonstrates that chronic treatment of DFMO depletes putrescine and decreases spermidine levels in the brain, inhibits growth, and impairs spatial learning and memory in the reference memory version of the water maze specifically. These findings merit further investigation to fully understand the functional role of endogenous polyamines in learning and memory.
机译：最近的证据表明，多胺Putrescine，Femerminine和Flemermine在维持正常细胞功能方面是必不可少的。本研究研究了二氟甲基胺（DFMO，饮用水3％）的慢性治疗的影响，腐凝水合成的有效抑制剂，连续54天在CA1，Ca2 / 3和牙齿旋转子系统中连续54天 - 海马和前额叶皮质的研究。 DFMO集团在地点导航中显示出性能损伤，探测试验24小时在训练后在训练中进行了参考记忆版的水迷宫任务，但不在升高的加迷宫，开放的场，对象识别，电动导航和工作中与对照组相比，水迷宫任务的记忆版（仅限饮用水）。在检查的四个脑区域中，DFMO处理分别导致普雷氏菌素和硫氨酸水平的减少约80-90％和20％，并且Ca2 / 3中的杏仁水平少量减少，对谷氨酸没有影响，谷氨酸和γ-氨基丁酸。 DFMO组相对于对照表示体重降低。然而，标准化脑，肾和肝重量之间的组之间没有显着差异。本研究表明，DFMO的慢性治疗DFMO耗尽普雷氏菌素并降低大脑中的亚精胺水平，抑制生长，并特别是在水迷宫的参考记忆版本中损害空间学习和记忆。这些调查结果进一步调查，以充分了解内源多胺在学习和记忆中的功能作用。

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