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Effect of chronic exposure to rimonabant and phytocannabinoids on anxiety-like behavior and saccharin palatability

机译:慢性暴露于剪枝系和植物植物植物对焦虑的行为和糖精可口性的影响

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The acute effects of cannabinoid compounds have been investigated in animal models of anxiety-like behavior and palatability processing. However, the chronic effects of cannabinoids in such models are poorly understood. Experiment 1 compared the effects of both acute and chronic (14 days) exposure to the CB1 receptor inverse agonist/antagonist, rimonabant, and the cannabis-derived CB1 receptor neutral antagonist, tetrahydrocannabivarin (THCV), on: 1) time spent in the open, lit box in the Light-Dark (LD) immersion model of anxiety-like behavior and 2) saccharin hedonic reactions in the taste reactivity (TR) test of palatability processing. Experiment 2 compared the effects of chronic administration of cannabis-derived ??9-tetrahydrocannabinol (??9-THC), cannabidiol (CBD) and cannabigerol (CBG) in these models. Tests were administered on Days 1, 7 and 14 of drug administration. In Experiment 1, rimonabant, but not THCV, produced an anxiogenic-like reaction in the LD immersion test and reduced saccharin palatability in the TR test; both of these effects occurred acutely and were not enhanced by chronic exposure. In Experiment 2, ??9- THC also produced an acute anxiogenic-like reaction in the LD immersion test, without enhancement by chronic exposure. However, ??9-THC enhanced saccharin palatability in the TR test on Day 1 of drug exposure only. CBD and CBG did not modify anxiety-like responding, but CBG produced a weak enhancement of saccharin palatability on Day 1 only. The results suggest that the anxiogenic-like reactions and the suppression of hedonic responding produced by rimonabant, are mediated by inverse agonism of the CB1 receptor and these effects are not enhanced with chronic exposure. ? 2012 Elsevier Inc. All rights reserved.
机译:大麻素化合物的急性效应已经研究了焦虑的行为和适口性加工的动物模型。然而,在这种模型中大麻素的慢性效应很难理解。实验1比较急性和慢性(14天)暴露于CB1受体反向激动剂/拮抗剂,乙二胺和大麻衍生的CB1受体中性拮抗剂,Tetrahydnabivarin(THCV),下:1)在开放的时间,LIT盒在焦虑的行为的焦虑(LD)浸泡模型中,2)糖精蜂窝反应在适应性加工的味道反应性(TR)试验中。实验2比较了这些模型中的慢性施用大麻衍生的慢性施用的慢性施用的慢性施用的慢性施用的9-四氢萘酚(CBD)和Cannabigerol(CBG)。试验在药物管理的第1,7和14天施用。在实验1中,乙烯甲烷类化合物,但不是THCV,在LD浸渍试验中产生了类似的反应,并在TR试验中降低了糖精可适口性;两种效应急性发生,并且通过慢性暴露并未增强。在实验2中,9-THC在LD浸渍试验中也产生了急性焦虑的反应,而不通过慢性暴露的增强。然而,在药物暴露的第1天的第1天的TR测试中,9-THC增强了糖精可口性。 CBD和CBG没有修饰焦虑的响应,但CBG仅在第1天产生了糖精的增强。结果表明,焦虑症状的焦虑反应和抑制rimonabant产生的衰减响应是通过CB1受体的反激激性介导的,并且这些作用不会随着慢性暴露而增强。还2012年elsevier Inc.保留所有权利。

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