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RU486 blocks effects of allopregnanolone on the response to restraint stress

机译：ru486阻断丙尼奥酮对抑制应力响应的影响

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These experiments were designed to provide information about the potential involvement of progesterone receptors in the ability of allopregnanolone (3??-hydroxy-5??-pregnan-20-one) to reduce the lordosis-inhibiting effects of restraint stress. Ovariectomized Fischer rats were hormonally primed with 10 ??g estradiol benzoate and 4 mg/kg allopregnanolone or vehicle. One hour before allopregnanolone, rats were injected with the progesterone receptor antagonist, RU486 (11??-(4-dimethylamino)phenyl-17??-hydroxy-17-(1- propynyl)estra-4,9-dien-3-one), or vehicle. Four hours after allopregnanolone or vehicle, sexual behavior was examined before and after a 5-min restraint stress. Lordosis behavior of rats primed only with estradiol benzoate declined after the 5 min of restraint while allopregnanolone prevented this decline. RU486 attenuated the ability of allopregnanolone to prevent the restraint-induced decline in lordosis behavior. These findings are consistent with earlier suggestions that progesterone receptors are involved in allopregnanolone's ability to reduce the effects of restraint stress. ? 2012 Elsevier Inc. All rights reserved.
机译：这些实验旨在提供有关孕酮受体潜在参与的信息，以在丙酸盐（3 ?? - 羟基-5 ?? - 妊娠-20-One）中，以减少抑制应激的脊髓源性抑制效果的能力。卵巢切除的费城大鼠用10℃苯甲酸苯甲酸酯和4mg / kg allopregheanolone或载体进行激素。在allopregheanolone前一小时，用孕酮受体拮抗剂注射大鼠ru486（11→ - （4-二甲基氨基）苯基-17-17-17-17-17-17-17 - 4,9-dien-3-一个）或车辆。在丙尼龙或载体后四小时，在5分钟的约束力应激之前和之后检查性行为。只有雌二醇苯甲酸酯在约束后的雌二醇苯甲酸酯下降的雄蕊行为，而丙尼奥酮均可阻止这种下降。 ru486衰减allopregnonolone以防止restraint诱导的脊柱尖端行为的能力。这些发现与早期提出的孕激素受体参与亚丙烯酸尼尔醌减少约束应激影响的能力。还2012年elsevier Inc.保留所有权利。

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