• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Morphine prevents the development of stress-enhanced fear learning
【24h】

Morphine prevents the development of stress-enhanced fear learning

机译：吗啡可防止发展压力增强的恐惧学习

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The current study investigates the pharmacotherapeutic use of morphine as a preventative treatment for stress-enhanced fear learning, an animal model that closely mimics symptoms of post-traumatic stress disorder (PTSD). PTSD is a chronic and debilitating anxiety disorder characterized by exaggerated fear and/or anxiety that may develop as a result of exposure to a traumatic event. In this model, rats are exposed to a severe stressor (15 foot shocks) in one environment (Context A) and then subsequently exposed to a milder form of the same stressor (single foot shock) in a different environment (Context B). Animals that did not receive prior shock treatment exhibit fear responsiveness to Context B in line with the severity of the single shock given in this context. Animals that had received prior shock treatment in Context A exhibit an exaggerated learned fear response to Context B. Furthermore, animals receiving a single dose of morphine immediately following the severe stressor in Context A continue to show an enhanced fear response in Context B. However, animals receiving repeated morphine administration (three injections) after exposure to the severe stressor in Context A or a single dose of morphine at 48 h after the severe stressor no longer exhibit an enhancement in fear learning to Context B. These results are consistent with clinical studies suggesting that morphine treatment following a severe stressor may be useful in preventing or reducing the severity of PTSD in at-risk populations. ? 2012 Elsevier Inc. All rights reserved.
机译：目前的研究调查了吗啡的药物治疗用作压力增强恐惧学习的预防性治疗，一种密切地模仿创伤后应激障碍（PTSD）的症状的动物模型。 PTSD是一种慢性和衰弱的焦虑症，其特征在于夸大的恐惧和/或焦虑，因为暴露于创伤事件而产生。在该模型中，大鼠在一个环境中暴露于严重的应激源（15英尺冲击）（上下文A），然后在不同的环境中暴露于相同的压力（单脚冲击）的更温和的形式（上下文B）。未收到的动物未收到的休克治疗表现出对上下文B的恐惧反应，与在这种情况下给出的单一冲击的严重程度。在语境中接受了先前休克治疗的动物表现出夸大的学习恐惧对上下文B的反应。此外，在语境A中，在严重的压力源之后，接受单剂量的吗啡在上下文B中继续显示增强的恐惧反应。然而，在严重的压力源在48小时后暴露于环境A或单剂量的语境中的重复压力源后接受重复的吗啡给药（三种注射），在严重的压力源中不再表现出恐惧学习的增强，对上下文B.这些结果与临床研究一致建议严重应激源后的吗啡治疗可用于预防或降低风险群体中的重点的严重程度。还2012年elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号