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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: Implication for osteoarthritis therapy
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Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: Implication for osteoarthritis therapy

机译：Inos抑制剂S-甲基噻吩脲在碘碘酸钠诱导的骨甲虫疼痛中的影响：对骨关节炎治疗的影响

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摘要

Much information is available on the role of nitric oxide (NO) in osteoarthritis (OA). However, its role has not been studied in the monosodium iodoacetate (MIA)-induced model of osteoarthritic pain. The present study was undertaken in rats to investigate the effect of iNOS inhibitor S-methylisothiourea (SMT) in MIA-induced osteoathritic pain and disease progression in rats. Osteoarthritis was produced by single intra-articular injection of the MIA in the right knee joint on day 0. Treatment groups were orally gavazed with different doses of SMT (10, 30 and 100 mg/kg) and etoricoxib (10 mg/kg) daily for 21 days. On days 0, 3, 7, 14 and 21, pain was measured and histopathology of right knee joint was done on day 21. SMT produced analgesia in a dose-dependent manner as shown by mechanical, heat hyperalgesia, knee vocalization, knee squeeze test, and spontaneous motor activity test. SMT reduced NO production in synovial fluid. Histopathological findings indicated that SMT reduced disease progression as evident from complete cartilage formation in rats treated with SMT at 30 mg/kg. In conclusion, the results indicate that SMT attenuates the MIA-induced pain and histopathological changes in the knee joint. The antinociceptive and antiarthritic effects of SMT were mediated by inhibiting cartilage damage and suppression of NO in synovial fluid. It is suggested that SMT has potential as a therapeutic modality in the treatment of osteoarthritis. ? 2013 Elsevier Inc.
机译：有很多信息可用于骨关节炎（OA）中的一氧化氮（NO）的作用。然而，它的作用尚未在碘碘酸碘钠（MIA）诱导的骨关节炎疼痛模型中进行。目前研究在大鼠中探讨了Inos抑制剂S-甲基噻脲（SMT）在大鼠中诱导的骨胸瘤疼痛和疾病进展的影响。在第0天的右侧膝关节中单个关节内注射骨髓炎。治疗组用不同剂量的SMT（10,30和100mg / kg）和每日肠道（10mg / kg）口服。治疗组21天。在第0,3,7,14和21天，测量疼痛和右膝关节的组织病理学在第21天进行。SMT产生的镇痛以剂量依赖性方式，如机械，热痛觉痛觉，膝关节，膝关节挤压试验所示，自发电机活动试验。 SMT在滑液中没有生产。组织病理学发现表明，在30mg / kg的大鼠治疗的大鼠中，SMT降低了疾病进展。总之，结果表明，SMT衰减了膝关节中的胶质诱导的疼痛和组织病理学变化。通过在滑液中抑制软骨损伤和抑制，SMT对SMT的抗运动性和抗炎效应。建议SMT在治疗骨关节炎时具有潜在的治疗方式。还2013年elsevier公司

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    MoreA.S.; KumariR.R.; GuptaG.; LingarajuM.C.; BalaganurV.; PathakN.N.; KumarD.; SharmaA.K.; TandanS.K.;

  • 作者单位

    Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar Bareilly;

    Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar Bareilly;

    Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar Bareilly;

    Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar Bareilly;

    Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar Bareilly;

    Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar Bareilly;

    Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar Bareilly;

    Division of Pathology Indian Veterinary Research Institute Izatnagar Bareilly U.P. 243 122;

    Division of Pharmacology and Toxicology Indian Veterinary Research Institute Izatnagar Bareilly;

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  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    iNOS; Monosodium iodoacetate; Osteoarthritis; Pain; S-methylisothiourea;

    机译：INOS;碘碘酸钠;骨关节炎;疼痛;S-甲基噻虫脲;

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