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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Mu-opioid blockade reduces ethanol effects on intake and behavior of the infant rat during short-term but not long-term social isolation
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Mu-opioid blockade reduces ethanol effects on intake and behavior of the infant rat during short-term but not long-term social isolation

机译：Mu-Apioid阻断减少了在短期内但不是长期社会隔离期间对婴儿大鼠的摄入和行为的乙醇影响

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Numerous findings in adult and infant rats have shown that the endogenous opioid system is involved in control of ethanol consumption and its reinforcing effects. Opioid systems are also involved in reactivity to social isolation with several factors (age, duration, and type of isolation) affecting this modulation. The present study investigated the effects of a selective mu-opioid antagonist CTOP (0, 0.1, 0.5 mg/kg), ethanol (0, 0.5 g/kg), and the interaction of the two drugs on the behavioral consequences of two types of social isolation given to preweanling rats: 1) short-term social isolation from littermates (STSI, duration 8 min) and 2) relatively long-term (5 h) isolation (LTSI) from the dam and littermates. Voluntary intake of saccharin, locomotion, rearing activity, paw licking, and grooming were assessed during an 8-min. intake test. Thermal nociceptive reactivity was also measured before and after the testing session with normalized differences in pre- and post-test latencies of paw withdrawal from a hot plate (49 C) used as an index of isolation-induced analgesia (IIA). The results indicate that pharmacological blockade of mu-opioid receptors by CTOP substantially attenuated ethanol's anxiolytic effects on the developing rat's reactions to social isolation. Some of these stress-attenuating effects of CTOP were observed only in animals exposed to short-term isolation (STSI) but not in pups isolated for 5 h (LTSI). Ethanol selectively increased saccharin intake during STSI in females and CTOP blocked this effect. Ethanol decreased the magnitude of analgesia associated with STSI but had no effect on pain reactivity during LTSI. CTOP by itself did not affect IIA or saccharin intake in sober animals. The findings of the present experiments indicate that the anxiolytic effects of 0.5 g/kg ethanol on pups exposed to STSI are modulated by endogenous opioid activity. ? 2012 Elsevier Inc.
机译：成人和婴儿大鼠的许多发现表明，内源性阿片类药物涉及控制乙醇消费及其增强效果。阿片类药物也参与了与影响该调制的几个因素（年龄，持续时间和隔离类型）的社会隔离的反应性。本研究研究了选择性Mu-Apioid拮抗剂CTOP（0,0.1,0.5mg / kg），乙醇（0,0.5g / kg）的影响，以及两种药物对两种类型的行为后果的相互作用给予惩罚大鼠的社会孤立：1）从凋落物（STSI，持续时间8分钟）和2）与大坝和凋落物的偶事（STSI，持续时间）和2）的短期社会隔离。在8分钟内评估了糖精，运动，饲养，爪子舔和美容的自愿摄入量。摄入测试。在测试会议之前和之后还测量了热伤害反应性，其在测试会议之前和之后，从热板（49c）中的爪子退出的预先和测试后延迟的常规差异用作分离诱导的镇痛指数（IIa）。结果表明，CTOP的MU-阿片受体的药理阻滞基本上减弱了乙醇对发展大鼠对社会分离的反应的抗焦力作用。只有在暴露于短期分离（STSI）的动物中只观察到CTOP的一些应激衰减效果，但不含幼崽（LTSI）。乙醇在女性和CTOP中选择性地增加糖精摄入量，CTOP阻止了这种效果。乙醇减少了与STSI相关​​的镇痛的大小，但在LTSI期间对疼痛反应性没有影响。 CTOP本身并不影响清醒动物中的IIA或糖精摄入量。本实验的发现表明，通过内源性阿片类化活性调节0.5g / kg乙醇对暴露于STSI的幼崽的抗焦力效应。还2012年elsevier公司

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