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首页> 外文期刊>Pharmacogenetics and genomics >A novel block at chromosome 12q24.1 is associated with coronary artery disease in Han Chinese populations
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A novel block at chromosome 12q24.1 is associated with coronary artery disease in Han Chinese populations

机译：染色体12季度12季度的一种新型嵌段与汉族人口中的冠状动脉疾病有关

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摘要

ObjectiveThe aim of this study was to refine the chromosomal region 12q24.1 associated with coronary artery disease in Han Chinese populations.Methods and resultsTwenty tagging single nucleotide polymorphisms covering 1.2Mb of chromosomal 12q24.1 were selected and genotyped in three geographically isolated case-control populations consisting of 7076 coronary artery disease (CAD) patients and non-CAD participants. In addition to replication of the previous block (block 1), we identified a novel block (block 2) associated with CAD. In a combined analysis, the odds ratio (95% confidence interval, permuted P value) were 0.79 (0.72-0.86, 8.358x10(-8)) and 1.24 (1.13-1.36, 2.576x10(-6)) for haplotypes ATGGG and GCACA in block 1 and 1.22 (1.14-1.30, 6.484x10(-9)) and 0.82 (0.77-0.88, 6.484x10(-9)) for haplotypes GA and AG in block 2, respectively. Protective alleles of two index single nucleotide polymorphisms decreased the expression of NAA25 (P=0.034), but did not alter the expression of other genes within block 2.ConclusionWe identified a novel block associated with CAD at chromosomal 12q24.
机译：本研究的客观目的是优化与汉族人群中冠状动脉疾病相关的染色体区域12q24.1.方法和结果标记覆盖1.2MB的染色体12Q24.1的单核苷酸多态性，并在三个地理上孤立案例控制中进行基因分型。由7076例冠状动脉疾病（CAD）患者和非CAD参与者组成的人群组成。除了先前块的复制之外（框1），我们还识别与CAD相关联的新颖块（框2）。在综合分析中，对单普型ATGGG和7.24（1.13-1.36,8.358x10（-8））和1.24（1.13-1.36,2.576×10（-6））的差异比（0.72-0.86,8.358×10（-6）））。在块1和1.22（1.14-1.30,6.484x10（-9））和0.82（0.77-0.88,6.484x10（-9））中的Gcaca分别用于单倍型Ga和块2中的0.82（0.77-0.88,6.484x10（-9））。两种指数单核苷酸多态性的保护等位基因降低了NaA25的表达（P = 0.034），但没有改变嵌段中的其他基因的表达。结论术语鉴定在染色体12Q24处鉴定了与CAD相关的新嵌段。

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  • 来源
    《Pharmacogenetics and genomics》 |2016年第11期|共8页
  • 作者

    Jiang Feng; Yan Han; Wu Chong; Song Chun; Zhao Bin; Li Yang; Dong Jie; Zheng Gu-Yan; Jin Li-Juan; Li Xue-Qi; Li Wei-Yang; Cai Jun; Yang Xin-Chun; Tian Xiao-Li;

  • 作者单位

    Capital Med Univ Beijing Chaoyang Hosp Dept Cardiol Beijing Peoples R China;

    Peking Univ Inst Mol Med Dept Human Populat Genet 5 Yiheyuan Rd Beijing 100871 Peoples R China;

    Peking Univ Inst Mol Med Dept Human Populat Genet 5 Yiheyuan Rd Beijing 100871 Peoples R China;

    Peking Univ Inst Mol Med Dept Human Populat Genet 5 Yiheyuan Rd Beijing 100871 Peoples R China;

    Peking Univ Inst Mol Med Dept Human Populat Genet 5 Yiheyuan Rd Beijing 100871 Peoples R China;

    Peking Univ Inst Mol Med Dept Human Populat Genet 5 Yiheyuan Rd Beijing 100871 Peoples R China;

    Peking Univ Inst Mol Med Dept Human Populat Genet 5 Yiheyuan Rd Beijing 100871 Peoples R China;

    Peking Univ Inst Mol Med Dept Human Populat Genet 5 Yiheyuan Rd Beijing 100871 Peoples R China;

    Harbin Med Univ Affiliated Hosp 2 Dept Cardiol Harbin Peoples R China;

    Harbin Med Univ Affiliated Hosp 4 Dept Cardiol Harbin Peoples R China;

    Mudanjiang Med Univ HongQi Hosp Dept Cardiol Mudanjiang Peoples R China;

    Capital Med Univ Beijing Chaoyang Hosp Dept Cardiol Beijing Peoples R China;

    Capital Med Univ Beijing Chaoyang Hosp Dept Cardiol Beijing Peoples R China;

    Peking Univ Inst Mol Med Dept Human Populat Genet 5 Yiheyuan Rd Beijing 100871 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    coronary artery disease; genetic association; Han Chinese; NAA25; 12q24; 1;

    机译：冠状动脉疾病;遗传学协会;汉族;NAA25;12Q24;1;

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