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Detecting Emerging Infectious Diseases: An Overview of the Laboratory Response Network for Biological Threats

机译：检测新兴传染病：生物威胁的实验室响应网络概述

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The Laboratory Response Network (LRN) was established in 1999 to ensure an effective laboratory response to high-priority public health threats. The LRN for biological threats (LRN-B) provides a laboratory infrastructure to respond to emerging infectious diseases. Since 2012, the LRN-B has been involved in 3 emerging infectious disease outbreak responses. We evaluated the LRN-B role in these responses and identified areas for improvement. LRN-B laboratories tested 1097 specimens during the 2014 Middle East Respiratory Syndrome Coronavirus outbreak, 180 specimens during the 2014-2015 Ebola outbreak, and 92 686 specimens during the 2016-2017 Zika virus outbreak. During the 2014-2015 Ebola outbreak, the LRN-B uncovered important gaps in biosafety and biosecurity practices. During the 2016-2017 Zika outbreak, the LRN-B identified the data entry bottleneck as a hindrance to timely reporting of results. Addressing areas for improvement may help LRN-B reference laboratories improve the response to future public health emergencies.
机译：实验室响应网络（LRN）成立于1999年，以确保对高优先级公共卫生威胁的有效的实验室反应。用于生物威胁的LRN（LRN-B）提供了实验室基础设施，以应对新兴的传染病。自2012年以来，LRN-B已参与3个新兴传染病爆发反应。我们在这些反应中评估了LRN-B在这些响应中的作用和确定的改进领域。 LRN-B实验室在2014年中东呼吸综合征冠状病毒爆发后测试了1097个标本，2014-2015埃博拉疫情的180个标本，以及2016-2017 Zika病毒爆发的92 686标本。在2014-2015埃博拉疫情期间，LRN-B在生物安全和生物安全实践中发现了重要的差距。在2016-2017 Zika爆发期间，LRN-B将数据输入瓶颈确定为障碍，以及时报告结果。解决方面的改进领域可能有助于LRN-B参考实验室改善对未来公共卫生紧急情况的反应。

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