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首页> 外文期刊>Ultrasound in Medicine and Biology >Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye
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Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye

机译：超声增强抗生素和抗炎药的递送到眼睛中

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摘要

Delivery of sufficient amounts of therapeutic drugs into the eye is often a challenging task. In this study, ultrasound application (frequencies of 400 KHz to 1 MHz, intensities of 0.3-1.0 W/cm2 and exposure duration of 5 min) was investigated to overcome the barrier properties of cornea, which is a typical route for topical administration of ophthalmic drugs. Permeability of ophthalmic drugs, tobramycin and dexamethasone and sodium fluorescein, a drug-mimicking compound, was studied in ultrasound- and sham-treated rabbit corneas in vitro using a standard diffusion cell setup. Light microscopy observations were used to determine ultrasound-induced structural changes in the cornea. For tobramycin, an increase in permeability for ultrasound- and sham-treated corneas was not statistically significant. Increase of 46%-126% and 32%-109% in corneal permeability was observed for sodium fluorescein and dexamethasone, respectively, with statistical significance (p 0.05) achieved at all treatment parameter combinations (compared with sham treatments) except for 1-MHz ultrasound applications for dexamethasone experiments. This permeability increase was highest at 400 kHz and appeared to be higher at higher intensities applied. Histologic analysis showed structural changes that were limited to epithelial layers of cornea. In summary, ultrasound application provided enhancement of drug delivery, increasing the permeability of the cornea for the anti-inflammatory ocular drug dexamethasone. Future investigations are needed to determine the effectiveness and safety of this application in in vivo long-term survival studies.
机译：向眼睛中递送足够量的治疗药是一个具有挑战性的任务。在本研究中，研究了超声施用（400kHz的频率为400kHz，强度为0.3-1.0W / cm2，暴露持续时间5分钟）以克服角膜的阻隔性能，这是局部施用眼科施用的典型途径药物。使用标准扩散单元设置，在超声波和假处理的兔角膜中研究了眼科药物，染发剂的渗透性，荧光素，荧光素，荧光素。光学显微镜观察用于确定角膜中的超声诱导的结构变化。对于录制霉素，对超声波和假处理的角膜渗透性的增加在统计学上没有统计学意义。对于荧光素和地塞米松，观察到荧光素和地塞米松的角膜渗透率增加46％-126％和32％-109％，统计学意义（P <0.05）除了1 -MHz超声波应用于地塞米松实验。这种渗透性升高在400 kHz的升高中最高，似乎在施加更高的强度下更高。组织学分析显示出限于角膜上皮层的结构变化。总之，超声应用提供了药物递送的增强，增加了角膜的渗透性，用于抗炎眼药物地塞米松。需要未来的调查来确定本申请在体内长期存活研究中的效果和安全性。

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    NabiliM.; PatelH.; MaheshS.P.; LiuJ.; GeistC.; ZdericV.;

  • 作者单位

    Department of Electrical and Computer Engineering The George Washington University Washington DC;

    Department of Electrical and Computer Engineering The George Washington University Washington DC;

    Department of Ophthalmology The George Washington University Washington DC United States;

    Department of Ophthalmology The George Washington University Washington DC United States;

    Department of Ophthalmology The George Washington University Washington DC United States;

    Department of Electrical and Computer Engineering The George Washington University Washington DC;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 影像诊断学;
  • 关键词

    Cornea; Drug delivery; In vitro; Ocular diseases; Sonophoresis; Therapeutic ultrasound;

    机译：角膜;药物递送;体外;眼部疾病;儿童抚养症;治疗超声;

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