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首页> 外文期刊>Ultrasound in Medicine and Biology >Non-Invasive Embolus Trap Using Histotripsy-An Acoustic Parameter Study
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Non-Invasive Embolus Trap Using Histotripsy-An Acoustic Parameter Study

机译：使用组织杆剂的非侵入性栓塞陷阱 - 一种声学参数研究

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摘要

Free-flowing particles in a blood vessel were observed to be attracted, trapped and eroded by a histotripsy bubble cloud. This phenomenon may be used to develop a non-invasive embolus trap (NET) to prevent embolization. This study investigates the effect of acoustic parameters on the trapping ability of the NET generated by a focused 1.063 MHz transducer. The maximum trapping velocity, defined by the maximum mean fluid velocity at which a 3-4 mm particle trapped in a 6 mm diameter vessel phantom, increased linearly with peak negative pressure (P-) and increased as the square root of pulse length and pulse repetition frequency (PRF). At 19.9 MPa P-, 1000 Hz PRF and 10 cycle pulse length, a 3 mm clot-mimicking particle could remain trapped under a background velocity of 9.7 cm/s. Clot fragments treated by NET resulted in debris particles <75 μm. These results will guide the appropriate selection of NET parameters.
机译：观察到血管中的自由流动的颗粒被组织脆性泡沫云吸引，捕获和侵蚀。 这种现象可用于开发非侵入性栓塞疏水阀（网）以防止栓塞。 本研究研究了声学参数对由聚焦1.063 MHz传感器产生的网的捕获能力的影响。 最大捕获速度，由3-4mm粒子捕获在6mm直径的血管体幻影中的最大平均流体速度，随着峰值负压（p°）而增加，并且随着脉冲长度和脉冲的平方根而增加 重复频率（PRF）。 在19.9MPa，1000Hz PRF和10个循环脉冲长度，3mm凝块模拟颗粒可以保持在9.7cm / s的背景速度下捕获。 通过网治疗的凝块片段导致碎片颗粒<75μm。 These results will guide the appropriate selection of NET parameters.

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    ParkS.; MaxwellA.D.; OwensG.E.; GurmH.S.; CainC.A.; XuZ.;

  • 作者单位

    Department of Biomedical Engineering University of Michigan Ann Arbor MI United States;

    Department of Biomedical Engineering University of Michigan Ann Arbor MI United States;

    Department of Biomedical Engineering University of Michigan Ann Arbor MI United States;

    Department of Internal Medicine University of Michigan Ann Arbor MI United States;

    Department of Biomedical Engineering University of Michigan Ann Arbor MI United States;

    Department of Biomedical Engineering University of Michigan Ann Arbor MI United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 影像诊断学;
  • 关键词

    Acoustic trapping; Cavitation; Emboli; Histotripsy; NET; Thrombolysis;

    机译：声学捕获;空化;栓子;组织杆菌;网;溶栓分析;

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