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首页> 外文期刊>Urological Science >Botulinum toxin A treatment for lower urinary tract symptoms/benign prostatic hyperplasia
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Botulinum toxin A treatment for lower urinary tract symptoms/benign prostatic hyperplasia

机译：肉毒杆菌毒素治疗尿路症状/良性前列腺增生

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摘要

Botulinum toxin A (BoNT-A) has been widely used in the treatment of overactive bladder and neurogenic detrusor overactivity. Recently, prostatic injection of BoNT-A had been tried to reduce the prostate volume and relieve lower urinary tract symptoms (LUTS) in patients with benign prostatic enlargement (BPE) due to benign prostatic hyperplasia (BPH). However, the efficacy of BoNT-A on BPE is still controversial. Traditionally, male LUTS have been considered as synonym of BPE because most male LUTS developed in aging men. Recent investigations have revealed that bladder dysfunction and bladder outlet dysfunction other than BPE contribute equally in male LUTS. Injecting BoNT-A into the prostatic urethra and bladder neck yielded improvement of LUTS, but not reduction of the prostatic volume, especially in men with small prostatic volume. The therapeutic effects of BoNT-A on LUTS might not be due to prostatic volume reduction, but through inhibiting the adrenergic hyperactivity in men with LUTS/BPH. This article discusses the current consensus and controversy of BoNT-A treatment on LUTS/BPH.
机译：肉毒杆菌毒素A（Bont-A）已被广泛用于治疗过度活性膀胱和神经源性排尿管过度效力。最近，由于良性前列腺增生（BPH），已经试图减少前列腺体积并减少前列腺体积，并减轻良性前列腺增大（BPE）的患者中的降低泌尿道症状（LUTS）。然而，Bont-A对BPE的功效仍然是争议的。传统上，雄性LUT被认为是BPE的同义词，因为老年人在老龄化男性中开发的大多数公迹。最近的调查显示，BPE以外的膀胱功能障碍和膀胱出口功能障碍在雄性LUT中贡献。注入前列腺尿道和膀胱颈的牙齿颈部产生改善，但不降低前列腺体积，特别是在具有小前列腺量的男性。 Bont-A对LUT的治疗效果可能是由于前列腺体积降低，而是通过抑制LUT / BPH的男性中的肾上腺素能多动。本文讨论了目前对LUT / BPH的聊天治疗的思考和争议。

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