Vitamin K epoxide reductase expression and prostate cancer risk

Tew Ben Yi; Pal Sumanta K.; He Miaoling; Tong Tommy; Wu Huiqing; Hsu JoAnn; Liu Xueli; Neuhausen Susan L.; Jones Jeremy O.

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Vitamin K epoxide reductase expression and prostate cancer risk

机译：维生素K环氧化物还原酶表达和前列腺癌风险

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Purpose:Increasing evidence has demonstrated that men taking the anticoagulant warfarin have a lower risk of developing prostate cancer. This phenomenon is not observed in other cancers. We sought to determine if the target of warfarin, vitamin K epoxide reductase (VKOR), is expressed in benign and cancerous prostate tissues and if a functional single nucleotide polymorphism (SNP) in the VKOR gene is associated with prostate cancer risk.

机译：目的：越来越多的证据表明，服用抗凝血华法林的男性患前列腺癌的风险较低。在其他癌症中未观察到这种现象。我们试图确定Warfarin，维生素K环氧化物还原酶（VKOR）的目标是否在良性和癌前列腺组织中表达，并且如果VKOR基因中的功能单核苷酸多态性（SNP）与前列腺癌风险有关。

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来源
《Urologic oncology》 |2017年第3期|共6页
作者
Tew Ben Yi; Pal Sumanta K.; He Miaoling; Tong Tommy; Wu Huiqing; Hsu JoAnn; Liu Xueli; Neuhausen Susan L.; Jones Jeremy O.;
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作者单位

City Hope Natl Med Ctr Beckman Res Inst Dept Canc Biol Duarte CA 91010 USA;

City Hope Natl Med Ctr Beckman Res Inst Dept Med Oncol Duarte CA 91010 USA;

City Hope Natl Med Ctr Beckman Res Inst Dept Canc Biol Duarte CA 91010 USA;

City Hope Natl Med Ctr Beckman Res Inst Dept Pathol Duarte CA 91010 USA;

City Hope Natl Med Ctr Beckman Res Inst Dept Pathol Duarte CA 91010 USA;

City Hope Natl Med Ctr Beckman Res Inst Dept Med Oncol Duarte CA 91010 USA;

City Hope Natl Med Ctr Beckman Res Inst Dept Biostat Duarte CA 91010 USA;

City Hope Natl Med Ctr Beckman Res Inst Dept Populat Sci Duarte CA 91010 USA;

City Hope Natl Med Ctr Beckman Res Inst Dept Canc Biol Duarte CA 91010 USA;

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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
Prostate cancer; Vitamin K epoxide reductase; Warfarin;

机译：前列腺癌;维生素K环氧化物还原酶;华法林;

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专利

1. Vitamin K epoxide reductase expression and prostate cancer risk [J] . Tew Ben Yi, Pal Sumanta K., He Miaoling, Urologic oncology . 2017,第3期

机译：维生素K环氧化物还原酶表达和前列腺癌风险
2. Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like [J] . VanHornW.D. Critical Reviews in Biochemistry and Molecular Biology . 2013,第4期

机译：对人体维生素K环氧还原酶和类似维生素K环氧还原酶的结构和功能的见解
3. Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2 [J] . Chu PH, Huang TY, Williams J, Proceedings of the National Academy of Sciences of the United States of America . 2006,第51期

机译：单独使用纯化的维生素K环氧还原酶足以将维生素K环氧转化为维生素K，并将维生素K转化为维生素KH2
4. TEMPORAL AND SPATIAL EXPRESSION PATTERNS OF PREGNANE X RECEPTOR AND VITAMIN K EPOXIDE REDUCTASE GENES, TWO CORE MOLECULAR PLAYERS ON FISH VITAMIN K HOMEOSTASIS AND SKELETAL DEVELOPMENT [C] . Ignacio Fernandez, M. Leonor Cancela, Paulo J. Gavaia. Annual Meeting of the European Aquaculture Society . 2013

机译：妊娠X受体和维生素K环氧化物还原酶基因的时间和空间表达模式，两种核心分子参与者对鱼维生素K稳态和骨骼发育
5. An Analysis of the Vitamin D Binding Protein Gene Variants and Associated Risks for Prostate Cancer Among African American Men. [D] . Mason, Kimberly Donice. 2014

机译：非洲裔美国男性中维生素D结合蛋白基因变异的分析和前列腺癌的相关风险。
6. Correction for Chu et al. Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2 [O] . 2014

机译：对Chu等人的修正仅纯化的维生素K环氧还原酶就足以将维生素K环氧转化为维生素K并将维生素K转化为维生素KH2
7. Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2 [O] . Chu, Pei-Hsuan, Huang, Teng-Yi, Williams, Jason, 2006

机译：单独使用纯化的维生素K环氧还原酶足以将维生素K环氧转化为维生素K，并将维生素K转化为维生素KH2

Vitamin K epoxide reductase expression and prostate cancer risk

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