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Meta-analysis of reference values of haemostatic markers during pregnancy and childbirth

机译:妊娠期和分娩期间止血症标志物参考值的荟萃分析

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Previously reported haemostatic reference intervals in normal pregnancy displayed considerable contradictions to establish convince gestational age-related haemostatic reference values. 30 clinical reports were recruited to collect and assemble existing clinical reports from the database D-dimer levels increased progressively with gestational ages and exceeded conventional value of 1 mg/L after 29-36 weeks, and reached a peak at 24 h postpartum with mean value of 6.44 mg/L [95% confidence interval (CI): 5.84 to 7.05] and returned to 0.79 mg/L (95% CI: 0.43 to 1.16) at 1-8 weeks postpartum. Analogously, the level of fibrinogen gradually increased throughout the pregnancy, and peaked at 48-72 h after birth, with mean value of 9.05 g/L (95% CI: 2.22 to 15.89) and then returned to 3.62 g/L (95% CI: 3.03 to 4.20) at 1-8 weeks postpartum. However, in the middle trimester, asynchronously prothromb in fragments 1 + 2 (F1+2) level elevated and reached a peak at 28-36 weeks with mean value of 3.05 nmol/L (95% CI: 2.41 to 3.70), and then decreased in the later trimester, and reached 1.92 nmol/L (95% CI: 0.58 to 3.27) at 48-72 h post-partum, close to normal levels. Previously reported gestational age-related haemostatic reference intervals in pregnancy could not be used as a standard. (c) 2018 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.
机译:以前报告的正常妊娠中的止血区间隔显示了相当大的矛盾,建立了与妊娠期与年龄相关的止血剂参考值相当矛盾。招募了30次临床报告,收集和组装来自数据库D-二聚体水平的现有临床报告逐渐随着妊娠年龄而增加,并且在29-36周后超过常规值为1mg / L,并在24小时后达到峰值,具有平均值。 6.44 mg / L [95%置信区间(CI):5.84至7.05],产后1-8周返回0.79mg / L(95%CI:0.43至1.16)。类似地,纤维蛋白原水平在整个妊娠过程中逐渐增加,出生后48-72小时达到峰值,平均值为9.05g / L(95%Ci:2.22至15.89),然后恢复为3.62g / L(95%在产后1-8周内,CI:3.03至4.20)。然而,在中间段中,在碎片1 + 2(F1 + 2)水平的异步prothromb升高并在28-36周的平均值为3.05 nmol / L(95%Ci:2.41至3.70)时达到峰值,然后在晚些时候达到妊娠后48-72小时,达到1.92 nmol / L(95%CI:0.58至3.27),达到了1.92米Nmol / L(95%CI:0.58至3.27)。以前报道的妊娠期妊娠期与妊娠期止血的参考间隔不能用作标准。 (c)2018台湾妇产科协会。 elsevier b.v的出版服务。

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