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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Short report: Potential for autoimmune pathogenesis of rift valley fever virus retinitis
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Short report: Potential for autoimmune pathogenesis of rift valley fever virus retinitis

机译：简短报告：裂谷裂谷病毒视网膜炎的自身免疫发病机制潜力

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摘要

Rift Valley Fever (RVF) is a significant threat to human health because it can progress to retinitis, encephalitis, and hemorrhagic fever. The timing of onset of Rift Valley Fever virus (RVFV) retinitis suggests an autoimmune origin. To determine whether RVFV retinitis is associated with increased levels of IgG against retinal tissue, we measured and compared levels of IgG against healthy human eye tissue by immunohistochemical analysis. We found that serum samples from RVFV-exposed Kenyans with retinitis (n = 8) were slightly more likely to have antibodies against retinal tissue than control populations, but the correlation was not statistically significant. Further investigation into the possible immune pathogenesis of RVFV retinitis could lead to improved therapies to prevent or treat this severe complication.
机译：Rift Valley Fever（RVF）对人类健康有重大威胁，因为它可以进入视网膜炎，脑炎和出血热。 裂谷发烧病毒（RVFV）视网膜炎的发作的时序表明了自身免疫起源。 为了确定RVFV视网膜炎是否与抗视网膜组织的IgG水平增加，我们通过免疫组化分析测量和比较了对健康人眼组织的IgG水平。 我们发现，来自RVFV暴露的kenyans的血清样品具有视网膜炎（n = 8）的可能性较小可能与视网膜组织的抗体比对照群体有抗体，但相关性在统计学上没有统计学意义。 进一步调查RVFV视网膜炎可能的免疫发病机制可能导致改善疗法以预防或治疗这种严重并发症。

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    Newman-GerhardtS.; MuiruriS.; MuchiriE.; PetersC.J.; MorrillJ.; LucasA.H.; KingC.H.; KazuraJ.; LaBeaudA.D.;

  • 作者单位

    Center for Immunobiology and Vaccine Development Children's Hospital Oakland Research Institute;

    Center for Immunobiology and Vaccine Development Children's Hospital Oakland Research Institute;

    Center for Immunobiology and Vaccine Development Children's Hospital Oakland Research Institute;

    Center for Immunobiology and Vaccine Development Children's Hospital Oakland Research Institute;

    Center for Immunobiology and Vaccine Development Children's Hospital Oakland Research Institute;

    Center for Immunobiology and Vaccine Development Children's Hospital Oakland Research Institute;

    Center for Immunobiology and Vaccine Development Children's Hospital Oakland Research Institute;

    Center for Immunobiology and Vaccine Development Children's Hospital Oakland Research Institute;

    Center for Immunobiology and Vaccine Development Children's Hospital Oakland Research Institute;

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  • 正文语种 eng
  • 中图分类 地方病学;
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