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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Diet quality, dietary inflammatory index and body mass index as predictors of response to adjunctive N-acetylcysteine and mitochondrial agents in adults with bipolar disorder: A sub-study of a randomised placebo-controlled trial
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Diet quality, dietary inflammatory index and body mass index as predictors of response to adjunctive N-acetylcysteine and mitochondrial agents in adults with bipolar disorder: A sub-study of a randomised placebo-controlled trial

机译：饮食质量，膳食炎症指数和体重指数作为对具有双相障碍的成人辅助N-乙酰半胱氨酸和线粒体剂的响应的预测因子：随机安慰剂对照试验的副研究

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Aims: We aimed to explore the relationships between diet quality, dietary inflammatory potential or body mass index and outcomes of a clinical trial of nutraceutical treatment for bipolar depression. Methods: This is a sub-study of a randomised controlled trial of participants with bipolar depression who provided dietary intake data (n = 133). Participants received 16 weeks adjunctive treatment of either placebo or N-acetylcysteine-alone or a combination of mitochondrial-enhancing nutraceuticals including N-acetylcysteine (combination treatment). Participants were followed up 4 weeks post-treatment discontinuation (Week 20). Diet was assessed by the Cancer Council Victoria Dietary Questionnaire for Epidemiological Studies, Version 2, converted into an Australian Recommended Food Score to measure diet quality, and energy-adjusted dietary inflammatory index score to measure inflammatory potential of diet. Body mass index was also measured. Generalised estimating equation models were used to assess whether diet quality, energy-adjusted dietary inflammatory index score and/or body mass index were predictors of response to significant outcomes of the primary trial: depression symptoms, clinician-rated improvement and functioning measures. Results: In participants taking combination treatment compared to placebo, change in depression scores was not predicted by Australian Recommended Food Score, dietary inflammatory index or body mass index scores. However, participants with better diet quality (Australian Recommended Food Score) reported reduced general depression and bipolar depression symptoms (p = 0.01 and p = 0.03, respectively) and greater clinician-rated improvement (p = 0.02) irrespective of treatment and time. Participants who had a more anti-inflammatory dietary inflammatory index had less impairment in functioning (p = 0.01). Combination treatment may attenuate the adverse effects of pro-inflammatory diet (p = 0.03) on functioning. Participants with lower body mass index who received combination treatment (p = 0.02) or N-acetylcysteine (p = 0.02) showed greater clinician-rated improvement. Conclusion: These data support a possible association between diet (quality and inflammatory potential), body mass index and response to treatment for bipolar depression in the context of a nutraceutical trial. The results should be interpreted cautiously because of limitations, including numerous null findings, modest sample size and being secondary analyses.
机译：目的：我们旨在探讨饮食质量，膳食炎症潜力或体重指数和临床试验对双极性抑郁症的临床试验的关系。方法：这是随机对照试验的与双极抑制的随机对照试验，患者提供膳食进气数据（n = 133）。与会者接受了16周的辅助治疗安慰剂或N-乙酰半胱氨酸 - 单独的或线粒体增强营养素的组合，包括N-乙酰半胱氨酸（组合处理）。参与者跟进治疗后4周后停药（第20周）。饮食评估了癌症委员会维多利亚饮食问卷的流行病学研究，版本2，转换为澳大利亚推荐的食物评分，以衡量饮食质量，节能饮食炎症指数评分测量饮食炎症潜力。还测量了体重指数。广义估计方程模型用于评估饮食质量，能量调节的膳食炎症指数评分和/或体重指数是否是对初级试验的显着结果的响应的预测因子：抑郁症状，临床医生额定改进和运作措施。结果：参与者采取联合治疗与安慰剂相比，澳大利亚推荐的粮食评分，膳食炎症指数或体重指数评分未预测抑郁症分数的变化。然而，与更好的饮食质量（澳大利亚推荐食物评分）的参与者报告了一般抑郁和双相抑郁症状（P = 0.01和P = 0.03），而且临床额定改善，无论治疗和时间如何。具有较为抗炎饮食炎症指数的参与者在功能损害下降（P = 0.01）。组合治疗可衰减促炎饮食（P = 0.03）的不良反应。接受组合处理（P = 0.02）或N-乙酰半胱氨酸（P = 0.02）的参与者显示出更高的临床医生额定改善。结论：这些数据支持在营养试验的背景下饮食（质量和炎症潜力），体重指数和对双极抑郁症治疗的反应之间的可能性。由于限制，包括众多空调，适度的样本大小以及次要分析，结果应谨慎地解释。

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  • 作者

    Ashton Melanie M.; Dean Olivia M.; Marx Wolfgang; Mohebbi Mohammadreza; Berk Michael; Malhi Gin S.; Ng Chee H.; Cotton Sue M.; Dodd Seetal; Sarris Jerome; Hopwood Malcolm; Faye-Chauhan Keshav; Kim Yesul; Dash Sarah R.; Jacka Felice N.; Shivappa Nitin; Hebert James R.; Turner Alyna;

  • 作者单位

    Deakin Univ Sch Med IMPACT Strateg Res Ctr Barwon Hlth HERB Bldg POB 281 Geelong Vic 3220;

    Deakin Univ Sch Med IMPACT Strateg Res Ctr Barwon Hlth HERB Bldg POB 281 Geelong Vic 3220;

    Deakin Univ Sch Med IMPACT Strateg Res Ctr Barwon Hlth HERB Bldg POB 281 Geelong Vic 3220;

    Deakin Univ Fac Hlth Biostat Unit Geelong Vic Australia;

    Deakin Univ Sch Med IMPACT Strateg Res Ctr Barwon Hlth HERB Bldg POB 281 Geelong Vic 3220;

    Northern Sydney Local Hlth Dist Acad Dept Psychiat St Leonards NSW Australia;

    Univ Melbourne Dept Psychiat Melbourne Clin Professorial Unit Richmond Vic Australia;

    Univ Melbourne Ctr Youth Mental Hlth Parkville Vic Australia;

    Deakin Univ Sch Med IMPACT Strateg Res Ctr Barwon Hlth HERB Bldg POB 281 Geelong Vic 3220;

    Univ Melbourne Dept Psychiat Melbourne Clin Professorial Unit Richmond Vic Australia;

    Univ Melbourne Dept Psychiat Albert Rd Clin Professorial Psychiat Unit Melbourne Vic Australia;

    Deakin Univ Sch Med IMPACT Strateg Res Ctr Barwon Hlth HERB Bldg POB 281 Geelong Vic 3220;

    Deakin Univ Sch Med IMPACT Strateg Res Ctr Barwon Hlth HERB Bldg POB 281 Geelong Vic 3220;

    Deakin Univ Sch Med IMPACT Strateg Res Ctr Barwon Hlth HERB Bldg POB 281 Geelong Vic 3220;

    Deakin Univ Sch Med IMPACT Strateg Res Ctr Barwon Hlth HERB Bldg POB 281 Geelong Vic 3220;

    Univ South Carolina Arnold Sch Publ Hlth Dept Epidemiol &

    Biostat Columbia SC 29208 USA;

    Univ South Carolina Arnold Sch Publ Hlth Dept Epidemiol &

    Biostat Columbia SC 29208 USA;

    Deakin Univ Sch Med IMPACT Strateg Res Ctr Barwon Hlth HERB Bldg POB 281 Geelong Vic 3220;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    Bipolar disorder; diet quality; dietary inflammatory index; body mass index; nutraceuticals;

    机译：双极障碍;饮食质量;膳食炎症指数;体重指数;营养保健品;

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