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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Drugs of abuse and increased risk of psychosis development.
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Drugs of abuse and increased risk of psychosis development.

机译：滥用药物和精神病发展风险增加。

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Objective: There is considerable evidence to suggest that the abuse of illicit drugs, particularly cannabis and methamphetamine, has aetiological roles in the pathogenesis of psychosis and schizophrenia. Factors that may increase susceptibility to the propsychotic effects of these drugs include the age at which the abuse starts as well as family history of genetic polymorphisms relevant to the pathophysiology of this disorder. However, the neurobiological mechanisms involved in drug abuse-associated psychosis remain largely unclear. Methods and Results: This paper presents an overview of the available evidence, including clinical, animal model, and molecular studies, with a focus on brain regions and neurotransmitters systems, such as dopamine and glutamate, previously implicated in psychosis. Conclusion: It is clear that further studies are urgently needed to provide a greater insight into the mechanisms that mediate the long-term and neurodevelopmental effects of cannabis and methamphetamine. A dialogue between basic science and clinical research may help to identify at-risk individuals and novel pathways for treatment and prevention.
机译：目的：有相当大的证据表明，滥用非法药物，特别是大麻和甲基甲基甲酸，在精神病和精神分裂症的发病机制中具有安全性的作用。可能增加对这些药物的致密效应易感性的因素包括滥用的年龄以及与该疾病的病理生理学相关的遗传多态性的家族史。然而，涉及药物滥用相关精神病症的神经生物学机制仍然很大程度上不清楚。方法和结果：本文提出了可用证据的概述，包括临床，动物模型和分子研究，重点关注脑区和神经递质系统，如多巴胺和谷氨酸，以前涉及精神病。结论很明显，迫切需要进一步研究，以便对介绍大麻和甲基苯丙胺的长期和神经发育效果的机制提供更大的洞察力。基础科学和临床研究之间的对话可能有助于识别风险的个人和新颖的治疗和预防途径。

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