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首页> 外文期刊>The European Journal of Neuroscience >A study of cortical and brainstem mechanisms of diffuse noxious inhibitory controls in anaesthetised normal and neuropathic rats
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A study of cortical and brainstem mechanisms of diffuse noxious inhibitory controls in anaesthetised normal and neuropathic rats

机译：麻醉正常和神经性大鼠弥漫性有毒抑制对照的皮质和脑干机制研究

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Diffuse noxious inhibitory controls (DNIC) are a mechanism of endogenous descending pain modulation and are deficient in a large proportion of chronic pain patients. However, the pathways involved remain only partially determined with several cortical and brainstem structures implicated. This study examined the role of the dorsal reticular nucleus (DRt) and infralimbic (ILC) region of the medial prefrontal cortex in DNIC. In vivo electrophysiology was performed to record from dorsal horn lamina V/VI wide dynamic range neurones with left hind paw receptive fields in anaesthetised sham-operated and L5/L6 spinal nerve-ligated (SNL) rats. Evoked neuronal responses were quantified in the presence and absence of a conditioning stimulus (left ear clamp). In sham rats, DNIC were reproducibly recruited by a heterotopically applied conditioning stimulus, an effect that was absent in neuropathic rats. Intra-DRt naloxone had no effect on spinal neuronal responses to dynamic brush, punctate mechanical, evaporative cooling and heat stimuli in sham and SNL rats. In addition, intra-DRt naloxone blocked DNIC in sham rats, but had no effect in SNL rats. Intra-ILC lidocaine had no effect on spinal neuronal responses to dynamic brush, punctate mechanical, evaporative cooling and heat stimuli in sham and SNL rats. However, differential effects were observed in relation to the expression of DNIC; intra-ILC lidocaine blocked activation of DNIC in sham rats but restored DNIC in SNL rats. These data suggest that the ILC is not directly involved in mediating DNIC but can modulate its activation and that DRt involvement in DNIC requires opioidergic signalling.
机译：弥漫性有毒抑制对照（DNIC）是内源性下降疼痛调节的机制，缺乏大部分慢性疼痛患者。然而，所涉及的途径仅涉及几种皮质和脑干结构的部分确定。该研究检测了中间前额叶皮质中的背网状核（DRT）和Infralimbic（ILC）区域在DNIC中的作用。在体内电生理学中，以麻醉假手术和L5 / L6脊神经连接（SN1）大鼠的左后爪接收领域，从背垫层覆盖V / VI宽动态范围神经元进行。在存在和不存在调节刺激（左耳夹）的情况下量化诱发的神经元反应。在恶意大鼠中，通过异相施加的调理刺激可重复招募DNIC，一种神经性大鼠中不存在的效果。 DRT内纳洛酮对Sham和SN1大鼠中的动态刷，点状机械，蒸发冷却和热刺激没有影响。此外，DRT内纳尔诺酮内含有沙拉的DNIC，但在SNL大鼠没有影响。 Incl-ILIDocaine对Sham和SN1大鼠中的动态刷，点状机械，蒸发冷却和热刺激没有影响脊髓神经元响应。然而，与DNIC的表达有关观察到差异效果; Intra-ILIDocaine在Sham大鼠中抑制了Dnic的活化，但在SNL大鼠中恢复了DNIC。这些数据表明，ILC不直接参与调解DNAT，但可以调节其激活，并且DRT参与DNIC需要opioidgic信令。

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