From clock to functional pacemaker

Michel Stephan; Meijer Johanna H.

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From clock to functional pacemaker

机译：从时钟到功能性起搏器

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In mammals, the central pacemaker that coordinates 24-hr rhythms is located in the suprachiasmatic nucleus (SCN). Individual neurons of the SCN have a molecular basis for rhythm generation and hence, they function as cell autonomous oscillators. Communication and synchronization among these neurons are crucial for obtaining a coherent rhythm at the population level, that can serve as a pace making signal for brain and body. Hence, the ability of single SCN neurons to produce circadian rhythms is equally important as the ability of these neurons to synchronize one another, to obtain a bona fide pacemaker at the SCN tissue level. In this chapter we will discuss the mechanisms underlying synchronization, and plasticity herein, which allows adaptation to changes in day length. Furthermore, we will discuss deterioration in synchronization among SCN neurons in aging, and gain in synchronization by voluntary physical activity or exercise.

机译：在哺乳动物中，坐标24-hr节律的中性起搏器位于Suprachiasmatic核（SCN）中。 SCN的个体神经元具有用于节律产生的分子基础，因此，它们用作细胞自主振荡器。这些神经元之间的通信和同步对于获得人口水平的相干节律至关重要，这可以作为脑和身体的速度制作信号。因此，单个SCN神经元产生昼夜节律的能力同样重要，因为这些神经元相互同步的能力，以获得SCN组织水平的真绒起搏器。在本章中，我们将讨论潜在的同步的机制，以及本文的可塑性，其允许适应日期长度的变化。此外，我们将讨论SCN神经元在老化中同步的恶化，并通过自愿身体活动或运动同步。

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来源
《The European Journal of Neuroscience》 |2020年第2期|共12页
作者
Michel Stephan; Meijer Johanna H.;
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作者单位

Leiden Univ Dept Cell &

Chem Biol Grp Neurophysiol Med Ctr Leiden Netherlands;

Leiden Univ Dept Cell &

Chem Biol Grp Neurophysiol Med Ctr Leiden Netherlands;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
in vivo electrophysiology; networks; photoperiod; SCN; synchronization;

机译：体内电生理;网络;PhotoPeriod;SCN;同步;

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1. Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model. [J] . Maltsev VA, Lakatta EG American Journal of Physiology . 2009,第3aPta1期

机译：耦合子路上CA2 +时钟和SARCOMMAL电压时钟的协同作用赋予了新型起搏器电池模型中的鲁棒和柔性起搏器功能。
2. Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model. [J] . Maltsev VA, Lakatta EG American Journal of Physiology . 2009,第3aPta1期

机译：耦合的肌膜下Ca 2+时钟和肌膜电压时钟的协同作用赋予新型起搏器细胞模型强大而灵活的起搏器功能。
3. Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility" [J] . LakattaE.G., YanivY., MaltsevV.A. American Journal of Physiology . 2013,第5aPta1期

机译：注意将心脏内在的生物钟与其内在的超心脏起搏器钟联系起来的间隙。专注于“心肌细胞分子时钟，Scn5a的调节和心律不齐的敏感性”
4. Clock gating assertion check: An approach towards achieving faster verification closure on clock gating functionality [C] . Zhong Wang Jian, Noh Norlaili Mohd, Rosdi Bakhtiar Affendi . 2015

机译：时钟门控断言检查：一种在时钟门控功能上实现更快的验证关闭的方法
5. Circadian organization in Japanese quail: Ocular clocks are pacemakers. [D] . Steele, Christopher Todd. 2005

机译：日本鹌鹑的昼夜节律组织：时钟是起搏器。
6. Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model [O] . Victor A. Maltsev, Edward G. Lakatta -1

机译：耦合的肌膜下Ca2 +时钟和肌膜电压时钟的协同作用在新型起搏器细胞模型中赋予强大而灵活的起搏器功能
7. Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model [O] . Maltsev, Victor A., Lakatta, Edward G. 2009

机译：耦合的肌膜下Ca2 +时钟和肌膜电压时钟的协同作用在新型起搏器细胞模型中赋予强大而灵活的起搏器功能

From clock to functional pacemaker

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