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首页> 外文期刊>The European Journal of Neuroscience >Cerebellar continuous theta-burst stimulation affects motor learning of voluntary arm movements in humans
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Cerebellar continuous theta-burst stimulation affects motor learning of voluntary arm movements in humans

机译：小脑连续的突然突发刺激影响人类自愿手臂运动的运动学习

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摘要

In this study we investigated in healthy subjects whether continuous theta-burst stimulation (cTBS) over the lateral cerebellum alters motor practice and retention phases during ipsilateral index finger and arm reaching movements. In 12 healthy subjects we delivered cTBS before repeated index finger abductions or arm reaching movements differing in complexity (reaching-to-grasp and reaching-to-point). We evaluated kinematic variables for index finger and arm reaching movements and changes in primary motor cortex (M1) activity tested with transcranial magnetic stimulation. Peak acceleration increased during motor practice for index finger abductions and reaching-to-grasp movements and persisted during motor retention. Peak acceleration decreased during motor practice for reaching-to-point movements and the decrease remained during motor retention. Cerebellar cTBS left the changes in peak acceleration during motor practice for index finger abductions and reaching-to-grasp arm movements unchanged but reduced peak acceleration at motor retention. Cerebellar cTBS prevented the decrease in peak acceleration for reaching-to-point movements during motor practice and at motor retention. Index finger abductions and arm reaching movements increased M1 excitability. Cerebellar cTBS decreased the motor evoked potential (MEP) facilitation induced by index finger movements, but increased the MEP facilitation after reaching-to-grasp and reaching-to-point movements. Cerebellar stimulation prevents motor retention for index finger abductions, reaching-to-grasp and reaching-to-point movements and degrades motor practice only for reaching-to-point movements. Cerebellar cTBS alters practice-related changes in M1 excitability depending on how intensely the cerebellum contributes to the task. Changes in M1 excitability reflect mechanisms of homeostatic plasticity elicited by the interaction of an 'exogenous' (cTBS-induced) and an 'endogenous' (motor practice-induced) plasticity-inducing protocol.
机译：在这项研究中，我们在健康受试者中调查了在横向小脑上连续θ-爆发刺激（CTBS）改变了在同侧指数手指和臂到达运动期间的运动实践和保留阶段。在12个健康的受试者中，我们在重复的指数手指绑架或臂达到不同于复杂性（到达抓住和到达点）之前交付了CTB。我们评估了用经颅磁刺激测试的指数手指和臂达到运动的运动变量和臂达到运动（M1）活性的变化。在电机实践中，峰值加速度增加了可食指的施工，并且在电动机保持期间持久地伸出牵引运动并持久。在电动机实践期间，峰值加速度降低，以达到点运动，并且在电动机保持过程中仍然减少。小脑CTBS在电机实践中留下峰值加速度的变化，用于指数手指绑架，到达抓住臂运动不变，但在电机保持下降低峰值加速度。小脑CTB阻止了在电机实践和电动机保持过程中达到点移动的峰值加速度的降低。食指绑架和臂达到运动提高了M1兴奋性。小脑CTBS减少了指数手指运动诱导的电动机诱发电位（MEP）促进，但在达到抓住后增加了MEP促进和达到点运动。小脑刺激防止电机保持用于指数手指伸位，伸向抓住和到达点运动，并仅降低电机实践，仅用于到达点运动。小脑CTBS改变了与练习相关的练习更改，这取决于小脑对任务的贡献程度有多强烈。 M1兴奋性的变化反映了“外源性”（CTBS诱导）和“内源性”（电机实践诱导的）可塑性诱导方案的相互作用引发了稳态塑性机制。

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