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首页> 外文期刊>The European Journal of Neuroscience >Long-lasting marked inhibition of periaqueductal gray-evoked defensive behaviors in inescapably-shocked rats
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Long-lasting marked inhibition of periaqueductal gray-evoked defensive behaviors in inescapably-shocked rats

机译：在不可缺失震惊的大鼠中持久持久的刺激性灰色灰诱发的防御性行为

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Clinical evidence suggests that depression and trauma predispose the subject to panic. Accordingly, here we examined the late effects of uncontrollable stress, a presumptive model of depression and/or traumatic disorder, on panic-like behaviors evoked by electrical stimulation of the dorsal periaqueductal gray (DPAG). Changes in anxiety and depression were also assessed in the elevated plus-maze (EPM) and forced-swimming test (FST), respectively. Rats with electrodes in the DPAG were subjected to a 7-day shuttle-box one-way escape yoked training with foot-shocks either escapable (ES) or inescapable (IS). The day after the end of one-way escape training, rats were trained in a two-way escape novel task (test-session) to ascertain the effectiveness of uncontrollable stress. DPAG stimulations were carried out in an open field, both before the escape training and 2 and 7 days after it, and EPM and FST were performed on the 8th and 10th days afterwards, respectively. Controls were either trained with fictive shocks (FS) or subjected to intracranial stimulations only. Although the ES rats performed significantly better than the IS group in the two-way escape task, groups did not differ with respect to either the anxiety or depression scores. Unexpectedly, however, IS rats showed a marked attenuation of DPAG-evoked freezing and flight behaviors relative to both the ES and FS groups, 2 and 7 days after one-way escape training. The conjoint inhibition of passive (freezing) and active (flight) defensive behaviors suggests that IS inhibits a DPAG in-built motivational system that may be implicated in depressed patients' difficulties in coping with daily-life stress.
机译：临床证据表明抑郁和创伤使受试者陷入恐慌。因此，在这里，我们检查了无法控制的应力，抑郁症和/或创伤性疾病的推定模型的晚期影响，这种行为在恐慌的恐慌刺激的恐慌的行为上被刺激的恐慌刺激灰色（DPAG）。在升高的加迷宫（EPM）和强制游泳试验（FST）中还评估了焦虑和抑郁症的变化。 DPAG中电极的大鼠进行7天的班车盒单向逃脱轭训练，脚踏障碍可逃脱或不可避免（是）。单向逃生培训结束后的第二天，大鼠培训以双向逃脱小组任务（测试会议）进行培训，以确定无法控制应力的有效性。 DPAG刺激在开放领域进行，在逃生训练和2和7天后，分别在第8天和第10天进行EPM和FST。控制要么具有虚构的冲击（FS）或仅受到颅内刺激的培训。虽然ES大鼠在双向逃生任务中比是群体的群体显着更好，但群体对焦虑或抑郁分数没有不同。然而，出乎意料地是大鼠表现出相对于ES和FS组的DPAG诱发的冰冻和飞行行为的显着衰减，在单向逃脱训练后2和7天。无源（冷冻）和活性（飞行）防守行为的联合抑制表明，这是抑制了可能涉及抑制患者在应对日常生活压力的困难中的DPAG内置动机系统。

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