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首页> 外文期刊>The European Journal of Neuroscience >Pro-neurotrophins, sortilin, and nociception
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Pro-neurotrophins, sortilin, and nociception

机译：Pro-neuroTroChins，Sortilin和Nocieption

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Nerve growth factor (NGF) signaling is important in the development and functional maintenance of nociceptors, but it also plays a central role in initiating and sustaining heat and mechanical hyperalgesia following inflammation. NGF signaling in pain has traditionally been thought of as primarily engaging the classic high-affinity receptor tyrosine kinase receptor TrkA to initiate sensitization events. However, the discovery that secreted proforms of nerve NGF have biological functions distinct from the processed mature factors raised the possibility that these proneurotrophins (proNTs) may have distinct function in painful conditions. ProNTs engage a novel receptor system that is distinct from that of mature neurotrophins, consisting of sortilin, a type I membrane protein belonging to the VPS10p family, and its co-receptor, the classic low-affinity neurotrophin receptor p75NTR. Here, we review how this new receptor system may itself function with or independently of the classic TrkA system in regulating inflammatory or neuropathic pain.
机译：神经生长因子（NGF）信号传导在伤害症的发育和功能性方面是重要的，但它也在炎症后启动和维持热和机械痛觉体中起着核心作用。疼痛中的NGF信号传统传统上被认为是主要接合经典的高亲和力受体酪氨酸激酶受体Trka以引发敏化事件。然而，发现神经NGF的分泌物的发现具有与加工成熟因子不同的生物学功能提出了这些易患这些易患条件下具有不同功能的可能性。垂直从事具有成熟神经营养素的新型受体系统，该系统与属于VPS10P家族的I型膜蛋白组成的成熟神经营养蛋白，以及其共同受体，经典的低亲和力神经营养蛋白受体P75TR。在这里，我们审查了这种新的受体系统如何在调节炎症或神经病疼痛方面具有或独立地使用或独立地运作。

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