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首页> 外文期刊>The European Journal of Neuroscience >Profiles of women in science: Carmen Sandi, President of the Federation of European Neuroscience Societies
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Profiles of women in science: Carmen Sandi, President of the Federation of European Neuroscience Societies

机译：妇女在科学中的概况：欧洲神经科学协会联合会主席Carmen Sandi

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Dietary omega‐3 fatty acids accumulate and are actively retained in central nervous system membranes, mainly in synapses, dendrites and photoreceptors. Despite this selective enrichment, their impact on synaptic function and plasticity has not been fully determined at the molecular level. In this study, we explored the impact of omega‐3 fatty acid deficiency on synaptic function in the hippocampus. Dietary omega‐3 fatty acid deficiency for 5 months after weaning led to a 65% reduction in the concentration of docosahexaenoic acid in whole brain synaptosomal phospholipids with no impact on global dopaminergic or serotonergic turnover. We observed reduced concentrations of glutamate receptor subunits, including GluA1, GluA2 and NR 2B, and synaptic vesicle proteins synaptophysin and synaptotagmin 1 in hippocampal synaptosomes of omega‐3 fatty acid‐deficient mice as compared to the omega‐3 fatty acid rich group. In contrast, an increased concentration of neuronal inositol 1,4,5‐trisphosphate‐receptor (IP 3‐R) was observed in the deficient group. Furthermore, omega‐3 fatty acid deficiency reduced the long‐term potentiation (LTP ) in stratum oriens of the hippocampal CA 1 area, but not in stratum radiatum. Thus, omega‐3 fatty acids seem to have specific effects in distinct subsets of glutamatergic synapses, suggesting specific molecular interactions in addition to altering plasma membrane properties on a more global scale.
机译：膳食ω-3脂肪酸积聚并积极保留在中枢神经系统膜中，主要是在突触，树突和感光体中。尽管有这种选择性富集，但它们对突触功能和可塑性的影响尚未在分子水平上完全确定。在这项研究中，我们探讨了Omega-3脂肪酸缺乏对海马突触功能的影响。断奶后饮食ω-3脂肪酸缺乏5个月导致全脑突触转移体磷脂中二十二世己烯酸浓度的65％降低，对全球多巴胺能或血清奈良加成交量没有影响。与ω-3脂肪酸缺陷小鼠的海马突触小鼠的海马突触小鼠中，观察到谷氨酸受体亚基的浓度降低，包括Glua1，Glua2和NR 2b，包括ω-3脂肪酸缺陷小鼠的突触囊泡蛋白突蛋白和Synaptotagmin 1。相反，在缺陷组中观察到神经元肌醇1,4,5-三种磷酸受体（IP 3-R）的增加浓度。此外，Omega-3脂肪酸缺乏减少了海马CA 1面积的角层，但不在层辐射中的长期增强（LTP）。因此，ω-3脂肪酸似乎在谷氨酸突突突突突出的不同亚群中具有特异性效果，这表明除了改变更换血浆膜特性的血浆膜特性以更大的全球范围内的特异性分子相互作用。

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