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首页> 外文期刊>The Canadian journal of hospital pharmacy. >THE 'CON' SIDE
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THE 'CON' SIDE

机译：“截然”

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Optimal blood pressure (BP) has been debated since hypertension was first identified more than 100 years ago as a cardiovascular risk factor. Previous trials have shown that reducing BP in elderly patients is beneficial.1"3 However, contrary to what golfers and limbo enthusiasts alike strive to achieve, lower—in the context of BP—is not always better. Two trials involving elderly Japanese patients (mean age 74 and 76 years, respectively) with a systolic BP above 160 mm Hg both demonstrated that "stria" BP control (systolic BP < 140 mm Hg) was not superior to "moderate" control (systolic BP 140-159 mm Hg) with respect to adverse cardiovascular and renal events.45 A subsequent meta-analysis assessed a BP target of < 160/ <90 mm Hg versus <140/<90 mm Hg in adults 65 years of age or older who had hypertension and found no difference in all-cause death and cardiovascular serious adverse events.6 The latest contribution to this debate is the Systolic Blood Pressure Intervention Trial (SPRINT), the seminal contemporary hypertension trial that has brought about countless metaphorical presentation tides at conferences worldwide. In that spirit, when it comes to intensive hypertension management in older adults, I would argue that we should walk rather than "SPRINT' toward a benefit.
机译：由于高血压首先将大于100年前作为心血管危险因素识别出高血压，因此最佳血压（BP）已被争论。以前的试验表明，在老年患者中减少了BP是有益的。“3然而，与高尔夫球手和Limbo爱好者同样相似，努力实现，低于BP的背景 - 并不总是更好。涉及老年日本患者的两项试验（平均74和76岁）分别具有160 mm Hg以上的收缩压BP，两者都证明了“Stria”BP对照（收缩性BP <140mM Hg）不优于“中等”对照（收缩压BP 140-159 mm Hg）关于不良心血管和肾脏事件.45随后的META分析评估了65岁或以上的成人中的<140 / <90毫米HG的BP靶标，患有高血压，发现没有差异在全因死亡和心血管严重的不良事件中.6对这场辩论的最新贡献是收缩压干预试验（Sprint），这是在全球会议上带来无数的隐喻介绍潮汐的精神上的血压干预试验。在T帽子精神，当涉及老年人的强化高血压管理时，我会争辩说我们应该走路而不是“冲刺”福利。

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