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首页> 外文期刊>The Canadian journal of hospital pharmacy. >A Canadian Survey of High-Dose Extended-Interval Gentamicin and Tobramycin in Pediatric Inpatients
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A Canadian Survey of High-Dose Extended-Interval Gentamicin and Tobramycin in Pediatric Inpatients

机译：高剂量延长间隔庆大霉素和毒素在儿科住院患者中的一个加拿大调查

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Background: The use of high-dose extended-interval (HDEI) aminoglycosides (AMG), a common practice in adult populations, is less established for pediatric patients, where AMGs are often dosed utilizing a multiple daily dosing method. Objectives: The purpose of this project was to characterize AMG prescribing practices in pediatric inpatients across Canada. The objective was to determine current practice of Canadian health care delivery organizations regarding HDEI gentamicin and tobramycin for pediatric inpatients, including their criteria and indications for use, dosing and monitoring practices, and extent of pharmacist authority to independently dose or monitor AMG. Methods: This study was comprised of an electronic survey of pharmacists in Canadian health care delivery organizations providing pediatric inpatient services. Questions focused on demographics, criteria for HDEI tobramycin or gentamicin use in pediatric inpatients, empiric dosing, and monitoring parameters as well as extent of pharmacist authority to independently dose and monitor AMGs at their institution. Results: Of the 45 survey participants (48% response rate), 35 (78%) indicated their health region uses HDEI tobramycin or gentamicin in pediatric inpatients. The population characteristics for use of HDEI AMG were varied. Dosing recommendations included 10 to 15 mg/kg for pulmonary exacerbations in cystic fibrosis, 5 to 8 mg/kg in urinary tract infections, and 6 to 9 mg/kg in febrile neutropenia. 89% of participants monitor serum levels and 77% monitor for nephrotoxicity. For prescriptive authority, 15.6% (7/45) of participants are authorized to independently adjust dosing at their institution and 31.1% (14/45) are authorized to order monitoring parameters. Conclusions: HDEI AMG is frequently utilized for pediatric patients across Canada, although the dosages and monitoring practices varied greatly. The information will be useful for creating a HDEI AMG pediatric protocol for use in the local health region, as well as for cross-comparison of practice by other centres across Canada.
机译：背景技术：使用高剂量延长间隔（HDEI）氨基糖苷（AMG），成年人群的常见做法，对儿科患者的常见做法较少，其中AMGS通常使用多种每日给药方法给药。目的：该项目的目的是在加拿大跨小儿住院患者进行AMG处方规定。目的是确定关于海参庆旺尼蛋白和对儿科住院患者的加拿大卫生保健递送组织的现行实践，包括他们的使用，给药和监测实践以及药物主义权，独立剂量或监测AMG的药剂师权力的标准和适应症。方法：本研究由提供儿科住院服务的加拿大医疗保健送货组织的药剂师电子调查组成。专注于人口统计学的问题，HDEI毒素的标准或庆大霉素用于小儿住院患者，经验剂给药以及监测参数以及药剂师权威的程度，在其机构独立和监测AMG。结果：45次调查参与者（48％的反应率），35（78％）表示，其卫生地区使用海氏霉素或儿科住院患者的庆大霉素。使用HDEI AMG的人口特征是不同的。给药推荐包括10至15mg / kg，用于膀胱纤维化，5至8毫克/千克的尿路感染5至8毫克/千克，可食用性纤维素感染6至9毫克/千克。 89％的参与者监测血清水平和77％的监测肾毒性。对于规定的授权，15.6％（7/45）名与会者被授权在其机构独立调整给药，31.1％（14/45）有权订购监测参数。结论：HDEI AMG经常用于加拿大的儿科患者，尽管剂量和监测实践变化了很大。这些信息对于创建HDEI AMG儿科议定书，可用于当地卫生区域，以及在加拿大跨其他中心的实践的交叉比较。

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