New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1.

Motohashi K; Hashimoto J; Inaba S; Khan ST; Komaki H; Nagai A; Takagi M; Shin ya K

首页> 外文期刊>The Journal of Antibiotics: An International Journal >New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1.

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New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1.

机译：新的Sesquiterpenes，JBir-27和-28，与剧烈衍生的真菌，Penicillium sp分离。 SS080624SCF1。

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In the course of our screening program for novel metabolites from tunicate-derived fungi, novel sesquiterpenoids, named JBIR-27 (1) and -28 (2), together with known sporogen-AO1 and phomenone, were isolated from the culture broth of Penicillium sp. SS080624SCf1. The structures of 1 and 2 were determined to be eremophilane analogs on the basis of extensive NMR and MS analyses. Sporogen-AO1, phomenone and 2 showed cytotoxicity against human cervical carcinoma cell line HeLa at IC(50) values of 8.3, 19 and 92 microM, respectively, whereas 1 was inactive at a concentration of 80 microM.

机译：在我们从统计衍生的真菌的新代谢物的筛查计划中，从青霉盐汤中分离出与已知的孢子素-A1和-28（2），与已知的孢子素-A1和Phomenone一起分离出来的新型Sesquiterpenoids，从青霉素的培养肉汤中分离出来 SP。 SS080624SCF1。基于广泛的NMR和MS分析，确定1和2的结构是Eremophilane类似物。 Sporogen-AO1，Phomenone和2分别在IC（50）值分别为8.3,19和92微米的人宫颈癌细胞系HeLa的细胞毒性，而1以80微米的浓度为无效。

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《The Journal of Antibiotics: An International Journal》 |2009年第5期|共4页
作者
Motohashi K; Hashimoto J; Inaba S; Khan ST; Komaki H; Nagai A; Takagi M; Shin ya K;
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Biomedicinal Information Research Center Japan Biological Informatics Consortium Tokyo Japan.;

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正文语种 eng
中图分类药学;
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1. New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1. [J] . Motohashi K, Hashimoto J, Inaba S, The Journal of Antibiotics: An International Journal . 2009,第5期

机译：新的倍半萜类，JBIR-27和-28，从被膜生真菌，青霉菌中分离。 SS080624SCf1。
2. JBIR-66, a New Metabolite Isolated from Tunicate-Derived Saccharopolyspora sp. SS081219JE-28 [J] . Motoki Takagi, Keiichiro Motohashi, Miho Izumikawa Bioscience, Biotechnology, and Biochemistry . 2010,第11期

机译：JBIR-66，一种新的代谢产物，分离自被膜来源的糖多孢菌种。 SS081219JE-28
3. Furanone derivative and sesquiterpene from Antarctic marine-derived fungus Penicillium sp. S-1-18 [J] . Zhou Yue, Li Yun-Hai, Yu Hao-Bing, Journal of Asian natural products research . 2018,第11a12期

机译：来自南极海洋衍生的真菌SP的呋喃酮衍生物和倍二萜。 S-1-18
4. Biotic Elicitor, Staphylococcus aureus, Stimulated Antibiotics Production from a Local Fungus of Tropical Peat Swamp Soil, Penicillium sp. LBKURCC34 [C] . Y. Nurulita, Yuharmen, A. Fitri, International Conference of the Indonesian Chemical Society . 2020

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5. Symbiotic effects of the fungus Glomus sp. on chromium(III), chromium(VI), and lead(II) uptake by mesquite (Prosopis sp.): A novel method to remediate heavy metals. [D] . Arias, Jack A. 2009

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6. Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus Penicillium sp. PR19N-1 [O] . Guangwei Wu, Aiqun Lin, Qianqun Gu, 2013

机译：来自南极深海衍生真菌Penicillium sp。的四种新的氯-Emmophilane倍半萜烯。 PR19N-1
7. Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1 [O] . Dehai Li, Tianjiao Zhu, Qianqun Gu, 2013

机译：来自南极深海衍生真菌penicillium sp。的四种新的氯 - Eremophilane倍半萜烯。 pR19N-1

New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1.

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