...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Compliance, Persistence, and Preferences Regarding Osteoporosis Treatment During Active Therapy or Drug Holiday
【24h】

Compliance, Persistence, and Preferences Regarding Osteoporosis Treatment During Active Therapy or Drug Holiday

机译：在活性治疗或毒品假期期间的依从性，持续性和偏好性疏松治疗

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Osteoporosis treatments reduce the risk of fractures by 30%-50%, but adherence after 1year is only about 50%. Drug holiday, a period with no active treatment, is part of routine management. The objective of this study was to determine compliance and persistence with osteoporosis therapy among postmenopausal women and to assess attitudes regarding treatment resumption among patients on drug holiday. This was a prospective observational study of patients followed at a dedicated metabolic bone clinic September 2013-February 2014. Compliance was assessed by medication possession ratio (MPR; number of doses dispensed relative to the number prescribed). Persistence was defined as continuation of treatment without a >30-day gap in prescription refills. Of 150 patients (70.1 +/- 8.1years), 57% were prescribed a medication: 64% oral, mostly bisphosphonates. MPR 80% was found in 80% and <50% in 12%; it was 100% for zoledronic acid and denosumab and 97%, 85%, 83%, and 70% for raloxifene, teriparatide, oral bisphosphonates, and strontium ranelate, respectively. Of 39 patients prescribed oral bisphosphonates, 77% persisted with treatment, and 89% took them as directed. Of 64 patients on a drug holiday, 59% expressed confidence in their physician's future treatment choice, whereas 19% expressed concerns about resuming treatment. Compliance among patients attending a dedicated bone clinic was higher than that reported in the literature. High persistence and compliance may be specific to patients followed in this type of setting. This study provides new information about attitudes of patients on a drug holiday. Most were not concerned about resuming treatment and did not have a preferred medication.
机译：骨质疏松症治疗将骨折的风险降低30％-50％，但1年后的粘附性仅为约50％。毒品假期，没有积极治疗的时期，是常规管理的一部分。本研究的目的是确定绝经后妇女骨质疏松症治疗的依从性和持续性，并评估患者患者患者的治疗恢复态度。这是对2013年9月至2013年9月的专用代谢骨诊所的患者的前瞻性观察研究。通过药物占有率（MPR;相对于规定的数量分配的剂量数量）评估合规性。持久性被定义为持续治疗，没有A处于处方式补充的> 30天的差距。 150名患者（70.1 +/- 8.1岁），57％的人进行了药物：64％口服，主要是双膦酸盐。 MPR 80％发现80％和<50％以内12％;对于唑酮酸和Denosumab为100％，分别为97％，85％，83％和70％，分别为雷洛昔芬，Triparatide，口服双膦酸盐和锶ranelate。在39例患者中，服用双膦酸盐，77％持续治疗，89％的人按照指示服用。在患者假期的64名患者中，59％对他们的医生未来的治疗选择表示信心，而19％对恢复治疗表示担忧。参加专用骨诊所的患者的符合性高于文献中报告的患者。高持久性和合规性可能是特定于这种环境的患者。本研究提供了有关患者毒品假期态度的新信息。大多数人并不担心恢复治疗，并且没有优选的药物治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号