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首页> 外文期刊>The journal of clinical psychiatry >A gender analysis of the study of pharmacotherapy of psychotic depression (STOP-PD): Gender and age as predictors of response and treatment-associated changes in body mass index and metabolic measures
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A gender analysis of the study of pharmacotherapy of psychotic depression (STOP-PD): Gender and age as predictors of response and treatment-associated changes in body mass index and metabolic measures

机译：精神病抑郁症药物治疗研究的性别分析（STOP-PD）：性别和年龄作为响应和治疗相关变化的预测因子和体重指数和代谢措施

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摘要

Background: Gender differences exist in psychiatric disorders; however, gender has not been well studied in psychotic depression. This analysis of the largest clinical trial in psychotic depression examined the effects of age and gender on clinical characteristics and predictors of treatment outcome and treatment-associated changes in body mass index (BMI) and metabolic measures. Method: Secondary analyses were performed on data from 259 subjects with major depressive disorder with psychotic features (DSM-IV-TR) aged 18-93 years in the double-blind randomized controlled trial of olanzapine plus sertraline versus olanzapine plus placebo for psychotic depression (Study of Pharmacotherapy of Psychotic Depression). Sociodemographic factors, clinical characteristics, treatment outcome, and treatment-associated changes in BMI and metabolic measures were analyzed by gender and age. Subjects were enrolled from December 2002 to June 2007. Results: Female gender was associated with divorced (Χ2 1 = 5.3, P = .03) or widowed (Χ 2 1 = 8.1, P ≤ .01) marital status. Comorbid anxiety disorders were more common in women than in men (Χ2 1 = 4.9, P = .03). Hallucinations (Χ2 1 = 7.8, P = .005) and delusions with disorganization (t257 = -2.10, P = .04) were significantly associated with female gender, as were higher cholesterol measures (Χ2 1 = 7.15, P = .008). There were no significant interactions between treatment and gender in terms of change in BMI. Gender was not associated with treatment response. Discussion: This study is the first analysis of gender and age as predictors of treatment outcome and treatment-associated changes in BMI and metabolic adverse effects in psychotic depression. Gender differences exist in patients with psychotic depression, most notably with regard to the presence of hallucinations. Female gender was associated with metabolic measures. Future studies with larger sample sizes may detect small gender differences in treatment outcome and treatment-associated changes in BMI and metabolic measures in psychotic depression.
机译：背景：精神病疾病中存在性别差异;然而，性别在精神病抑郁症中尚未得到很好的研究。对精神病抑郁症最大临床试验的这种分析检测了年龄和性别对体重指数（BMI）和代谢措施治疗结果和治疗相关变化的临床特征和预测因子。方法：对来自259名受试者的数据进行二次分析，其具有18-93岁的精神功能（DSM-IV-TR）在奥兰扎滨加上塞拉齐滨的双盲随机对照试验，对精神病抑制（精神病抑郁症的药物治疗。通过性别和年龄分析了BMI和代谢措施的临床特征，治疗结果和治疗相关变化。受试者于2002年12月至2007年6月招募。结果：女性性别与离婚有关（χ21= 5.3，p = .03）或丧偶（χ21= 8.1，p≤01）婚姻状况。合并焦虑症在女性中比男性更常见（χ21= 4.9，p = .03）。幻觉（χ21= 7.8，p = .005）和妄想（T257 = -2.10，p = .04）与女性性别显着相关，如较高的胆固醇措施（χ21= 7.15，p = .008） 。在BMI的变化方面，治疗和性别之间没有显着的相互作用。性别与治疗反应无​​关。讨论：本研究是对治疗结果的预测性和治疗相关变化的性别和年龄的第一次分析，并在精神病抑郁症中的代谢不良反应。心理学抑郁症患者存在性别差异，最值得注意的是幻觉的存在。女性性别与代谢措施有关。具有较大样本尺寸的未来研究可能会检测到治疗结果和治疗相关变化的少量性别差异，并在精神病抑郁症中的代谢措施。

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  • 来源
    《The journal of clinical psychiatry》 |2013年第10期|共7页
  • 作者

    DeligiannidisK.M.; RothschildA.J.; BartonB.A.; Kroll-DesrosiersA.R.; MeyersB.S.; FlintA.J.; WhyteE.M.; MulsantB.H.;

  • 作者单位

    Center for Psychopharmacologic Research and Treatment University of Massachusetts Medical School;

    Center for Psychopharmacologic Research and Treatment University of Massachusetts Medical School;

    Center for Psychopharmacologic Research and Treatment University of Massachusetts Medical School;

    Center for Psychopharmacologic Research and Treatment University of Massachusetts Medical School;

    Weill Medical College of Cornell University New York Presbyterian Hospital New York United States;

    University Health Network Toronto ON Canada Department of Psychiatry University of Toronto;

    Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh;

    Department of Psychiatry University of Toronto Toronto ON Canada Centre for Addiction and;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 精神病学;
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