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首页> 外文期刊>The journal of sexual medicine >Role of Nanotechnology in Erectile Dysfunction Treatment
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Role of Nanotechnology in Erectile Dysfunction Treatment

机译：纳米技术在勃起功能障碍治疗中的作用

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Abstract Introduction The biological importance of nanotechnology-based delivery vehicles for in?vivo tissue regeneration is gaining acceptance by the medical community; however, its relevance and incorporation into the treatment of sexual dysfunction are evolving and have not been well evaluated. Aim To provide scientific evidence examining the use of state-of-the-art nanotechnology-based delivery methodology in the treatment of erectile dysfunction (ED) in animal models and in patients. Methods This review assessed the current basic science literature examining the role of nanotechnology-based delivery vehicles in the development of potential ED therapies. Results There are four primary areas where nanotechnology has been applied for ED treatment: (i) topical delivery of drugs for on-demand erectile function, (ii) injectable gels into the penis to prevent morphologic changes after prostatectomy, (iii) hydrogels to promote cavernous nerve regeneration or neuroprotection, and (iv) encapsulation of drugs to increase erectile function (primarily of phosphodiesterase type 5 inhibitors). Conclusion Basic science studies provide evidence for a significant and evolving role for nanotechnology in the development of therapies for ED and suggest that properly administered nano-based therapies might be advantageous for treating male sexual dysfunction.
机译：摘要引言基于纳米技术的送货车辆的生物重要性？体内组织再生是医学界的接受;然而，它的相关性和掺入性功能障碍的治疗正在进行，并且尚未得到很好的评估。旨在提供科学证据，检查使用最先进的纳米技术的递送方法，治疗动物模型和患者的勃起功能障碍（ED）。方法评估评估目前的基础科学文献检查了基于纳米技术的送货车在潜在的艾德疗法发展中的作用。结果有四个主要区域，纳米技术已申请ED治疗：（i）用于按需勃起功能的药物局部递送，（ii）注射凝胶进入阴茎，以防止前列腺切除术后的形态学变化，（iii）水凝胶以促进海绵状神经再生或神经保护剂，（iv）药物的包封，以增加勃起功能（主要是磷酸二酯酶类型5抑制剂）。结论基础科学研究为纳米技术在培养的疗法发展中提供了显着和不断发展的作用，并表明适当施用的纳米疗法可能是有利的，可治疗男性性功能障碍。

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