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Effects of Low-Intensity Extracorporeal Shockwave Therapy on Erectile Dysfunction: A Systematic Review and Meta-Analysis

机译:低强度体外冲击波治疗对勃起功能障碍的影响:系统评价和荟萃分析

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Abstract Introduction Low-intensity extracorporeal shock wave therapy (Li-ESWT) has been proposed as an effective non-invasive treatment option for erectile dysfunction (ED). Aim To use systematic review and meta-analysis to assess the efficacy of Li-ESWT by comparing change in erectile function as assessed by the erectile function domain of the International Index of Erectile Function (IIEF-EF) in men undergoing Li-ESWT vs sham therapy for the treatment of ED. Methods Systematic search was conducted of MEDLINE, EMBASE, and ClinicalTrials.gov for randomized controlled trials that were published in peer-reviewed journals or presented in abstract form of Li-ESWT used for the treatment of ED from January 2010 through March 2016. Randomized controlled trials were eligible for inclusion if they were published in the peer-reviewed literature and assessed erectile function outcomes using the IIEF-EF score. Estimates were pooled using random-effects meta-analysis. Main Outcome Measures Change in IIEF-EF score after treatment with Li-ESWT in patients treated with active treatment vs sham Li-ESWT probes. Results Data were extracted from seven trials involving 602 participants. The average age was 60.7 years and the average follow-up was 19.8 weeks. There was a statistically significant improvement in pooled change in IIEF-EF score from baseline to follow-up in men undergoing Li-ESWT vs those undergoing sham therapy (6.40?points; 95% CI?= 1.78–11.02; I 2 ?= 98.7%; P .0001 vs 1.65 points; 95% CI?= 0.92–2.39; I 2 ?=?64.6%; P .0001; between-group difference, P ?= .047). Significant between-group differences were found for total treatment shocks received by patients ( P .0001). Conclusion In this meta-analysis of seven randomized controlled trials, treatment of ED with Li-ESWT resulted in a significant increase in IIEF-EF scores.
机译:摘要介绍低强度体外冲击波治疗(LI-ESWT)已被提出为勃起功能障碍(ED)的有效的非侵入性治疗选择。旨在使用系统评价和荟萃分析来评估LI-ESWT通过比较勃起函数域(IIEIE-EIEIE-EF)的勃起函数领域的勃起函数领域(IIEIE-EIEIE-EIEV)的勃起函数域(IIEIE-EIEIE-EIEV)的变化来评估勃起功能的疗效。治疗ED治疗。方法对系统检索进行系统检索,用于随机对照试验进行,随机对照试验,该试验在同行评审期刊上发表,或者以2016年1月至2010年1月从2010年1月到2010年3月治疗ED的摘要形式。随机控制如果他们在同行评审文献中发表并使用IIEIE-EIEC-EIEC分数评估勃起函数结果,试验有资格包容。使用随机效应元分析汇总估计。在用活性治疗治疗的患者对患者治疗后,主要结果测量IIET-EIEC-EF评分的变化VS Sham Li-ESWT探头。结果从涉及602名参与者的七项试验中提取数据。平均年龄为60.7岁,平均随访是19.8周。统计上显着改善IIET-EIEC-EIED-EIEF-EIEC-EIEF-EIEC-EIED的变化从遭受脑卒中的男性的后续行动(6.40?点; 95%CI?= 1.78-11.02; I 2?= 98.7 %; p& .0001与1.65点; 95%ci?= 0.92-2.39; I 2?= 64.6%; p& 0001; - 组差异,p?= .047)。患者收到的总治疗冲击(P <.0001),发现了组间差异的显着差异。结论在七项随机对照试验的这种荟萃分析中,用LI-ESWT治疗ED导致IIET-EIEIE-EF的分数显着增加。

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