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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Development of a Rat Clinical Frailty Index
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Development of a Rat Clinical Frailty Index

机译：大鼠临床体力指数的发展

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Rats are a commonly used model for aging studies, and a frailty assessment tool for rats would be of considerable value. There has been a recent focus on the development of preclinical models of frailty in mice. A mouse clinical frailty index (FI) was developed based on clinical frailty assessment tools. This FI measures the accumulation of clinically evident health-related deficits in mice. This paper aimed to develop a rat clinical FI. Male Fischer 344 rats were aged from 6 to 9 months (n = 12), and from 13 to 21 months (n = 41). A FI comprised of 27 health-related deficits was developed from a review of the literature and consultation with a veterinarian. Deficits were scored 0 if absent, 0.5 if mild, or 1 if severe. A FI score was determined for each rat every 3-4 months, and for the older group mortality was assessed up to 21 months. Mean FI scores significantly increased at each time point for the older rats. A high FI score measured at both 17 months of age and terminally was also associated with decreased probability of survival as assessed with Kaplan-Meier curves. The rat clinical FI has significant value for use in aging and interventional studies.
机译：大鼠是一种常用的老化研究模型，对于大鼠的脆弱性评估工具将具有相当大的价值。近来始终侧重于小鼠脆弱临界模型的发展。基于临床体力评估工具开发了鼠标临床脆弱指数（FI）。这一发现衡量小鼠临床明显的健康相关赤字的积累。本文旨在开发大鼠临床FI。雄性费氏344大鼠从6至9个月（n = 12），13至21个月（n = 41）。由与兽医的文献和协商审查制定了由27个与健康有关的赤字组成的FI。如果缺席，如果不存在0.5，如果温和，或者1，如果严重，则赤字得分为0。每3-4个月每3-4个月确定每只大鼠的比分，并且较旧的群体死亡率最多可评估21个月。在较旧大鼠的每个时间点，平均值显着增加。在17个月和终端中测量的高分辨率也与随着KAPLAN-MEIER曲线评估的评估时的存活率下降有关。大鼠临床FI具有显着的衰老和介入研究的价值。

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