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首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Progressive loss of nigrostriatal dopaminergic neurons induced by inflammatory responses to fipronil
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Progressive loss of nigrostriatal dopaminergic neurons induced by inflammatory responses to fipronil

机译：对炎症反应诱导的抗瘤性多巴胺能神经元的渐进式丧失

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摘要

Inflammatory responses are involved in mechanisms of neuronal cell damage in the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD). We investigated the mechanisms whereby inflammatory responses contribute to loss of dopaminergic neurons in fipronil (FPN)-treated rats. After stereotaxic injection of FPN in the substantia nigra (SN), the number of tyrosine hydroxylase (TH)-positive neurons and the levels of TH expression in the SN decreased at 7 days, and a significant decrease was observed at 14 days with a subsequent reduction in striatal TH expression. Decreases in dopamine (DA) levels, however, began at 3 days post-injection, preceding the changes in TH expression. In contrast, glial fibrillary acidic protein (GFAP) expression was significantly increased at 3 days and persisted for up to 14 days post-lesion; these changes in GFAP expression appeared to be inversely correlated with TH expression. Furthermore, we found that FPN administration induced an inflammatory response characterized by increased levels of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha), which was mediated by activated microglia following infusion of FPN unilaterally into the SN. Intranigral injection of FPN underwent an inflammatory response with a resultant ongoing loss of dopaminergic neurons, indicating that pesticides may have important implication for the study of PD. Crown Copyright (C) 2016 Published by Elsevier Ireland Ltd. All
机译：炎症反应参与神经元细胞损伤在神经变性疾病的发病机制中的机制，例如帕金森病（PD）。我们调查了炎症反应导致FIPRONIL（FPN） - 治疗大鼠的多巴胺能神经元有助于损失的机制。在实体内注射FPN中，在体内NIGRA（SN）中，酪氨酸羟化酶（TH） - 阳性神经元的数量和SN中的Th表达水平在7天下降，并在随后的14天观察到显着降低减少纹状体表达。然而，多巴胺（DA）水平降低，始于注射后3天，在表达式的变化之前。相比之下，胶质纤维状酸性蛋白（GFAP）表达在3天显着增加，后病变后持续14天; GFAP表达式的这些变化似乎与Th表达式相反。此外，我们发现FPN施用诱导炎症反应，其特征在于通过活性微胶质细胞介导的诱导型没有合酶（InOS），环氧化酶-2（COX-2）和肿瘤坏死因子-α（TNF-α）的水平增加。在单方面输注FPN进入SN。患有FPN的肺部注射患有由此产生的多巴胺能神经元的炎症反应，表明农药可能对PD的研究具有重要意义。皇冠版权（c）2016由elsevier爱尔兰有限公司出版

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