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首页> 外文期刊>Transactions of the Royal Society of Tropical Medicine and Hygiene >Plasmodium vivax malaria in Duffy-negative individuals from Ethiopia.
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Plasmodium vivax malaria in Duffy-negative individuals from Ethiopia.

机译：埃塞俄比亚的Duffy阴性疟疾疟疾疟疾。

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摘要

This study was conducted to estimate the prevalence of Plasmodium vivax and polymorphisms in the Duffy antigen receptor for chemokines (DARC) gene in patients with suspected malaria from eastern (Harar) and southwestern (Jimma) Ethiopia.Plasmodium presence and species was assessed by microscopy in 1304 and 627 febrile patients in Harar and Jimma, respectively, during October-November 2009. All microscopy-positive samples were confirmed by PCR. DARC gene polymorphisms were identified by DNA sequencing.Plasmodium vivax was the dominant species in Harar (74/98, 76%) and P. falciparum was more common in Jimma (70/107, 65%). We found 17/98 (17%) and 24/107 (22%) homozygous Duffy-negative patients in Harar and Jimma, respectively. Unexpectedly, three Duffy-negative patients from Harar had P. vivax malaria.This study documents the emergence of P. vivax malaria in Duffy-negative individuals in Ethiopia. The Duffy-negative blood group does not appear to provide absolute protection against P. vivax infection in this region.
机译：进行该研究以估计疑似疟疾患者（Harar）和西南部（Jimma）埃塞俄比亚患者患有趋化因子（DARC）基因的疟原虫抗原受体中疟原虫抗原受体的疟原虫（DARC）基因的多态性。通过显微镜评估存在和物种。在2009年10月至11月，分别在Harar和Jimma的1304和627患者。通过PCR确认所有显微镜阳性样品。 DNA测序鉴定了DARC基因多态性。vivax是哈拉尔（74/98,76％）和P. falciparum在吉米（70/107,65％）中的显性种类。我们发现了哈拉和吉玛的17/98（17％）和24/107（22％）纯合的雄囊阴性患者。出乎意料地，来自Harar的三名达菲阴性患者患有P.Vivax疟疾。本研究文件记录了埃塞俄比亚的Duffy阴性患者的P.Vivax疟疾的出现。 Duffy阴性血液组似​​乎没有提供该地区对vivax感染的绝对保护。

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