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首页> 外文期刊>Trends in Ecology & Evolution >Small and intermediate Ca2+-sensitive K+ channels do not play a role in vascular conductance during resting blood flow in the anaesthetised pig
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Small and intermediate Ca2+-sensitive K+ channels do not play a role in vascular conductance during resting blood flow in the anaesthetised pig

机译：在休息麻醉猪中的血液流动期间，小和中间CA2 + -ScA2 + -Siscy K +通道不会在血管传导中发挥作用

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摘要

Flow-induced dilation in resistance arteries is mediated by endothelium-dependent hyperpolarisation via small and intermediate conducting Ca2+ sensitive K+ channels. The aim of the current study was to assess the effect of blocking both channels, using the toxins apamin and charybdotoxin, on flow-induced dilation in a conduit artery and vascular conductance. Experiments were carried out on the iliac and its vascular bed in anaesthetised pigs (n = 4). Flow-induced dilation and vascular conductance ( increment F/ increment P) were assessed before and after administration of toxins intra-arterially (i.a.) at 50 mu g kg(-1). Iliac diameter increased from baseline to 2.39 +/- 0.4 mm before and 2.09 +/- 0.46 mm after toxin administration, which was not significantly different (P = 0.63, Student's paired t test). Control conductance was 1.49 +/- 0.27 ml min(-1) mmHg(-1) (P < 0.00001, ANOVA), and 1.53 +/- 0.18 ml min(-1) mmHg(-1) (P < 0.00001, ANOVA) in the presence of the toxins which was not significantly different (P = 0.93 homogeneity of regression analysis). There was a small but significant increase in mean arterial pressure after the toxins were administered, from 74 +/- 5 to 80 +/- 9 mmHg (P = 0.03, Student's paired t test); but all other measured parameters were not significantly affected. Small- and intermediate-conducting Ca2+-sensitive K+ channels are not involved in flow-mediated dilation in conduit arteries and do not play a role in resistance vessel diameter maintenance at resting blood flow.
机译：通过小和中间导电Ca2 +敏感k +通道，通过内皮依赖性超极化介导的流动诱导的抗性动脉的扩张。目前研究的目的是评估使用毒素Apamin和Charybdotoxin阻断两个通道的效果，在导管动脉和血管传导中流动诱导的扩张。在麻醉猪中对髂骨和血管床进行实验（n = 4）。在50μgkg（-1）的前后，评估流动诱导的扩张和血管传导（增量f /增量p）。髂直径从基线增加到2.39 +/- 0.4 mm，毒素给药后2.09 +/- 0.46mm，这没有显着差异（P = 0.63，学生配对T测试）。控制电导为1.49 +/- 0.27 mL min（-1）mmHg（-1）（p <0.00001，Anova）和1.53 +/- 0.18 ml min（-1）mmHg（-1）（p <0.00001，Anova ）在没有显着不同的毒素存在下（P = 0.93回归分析的均匀性）。在给予毒素后，在毒素施用后，毒素的平均动脉压显着增加，74 +/- 5至80 +/- 9 mmHg（P = 0.03，学生配对T测试）;但所有其他测量的参数都不会受到显着影响。小和中间导电Ca2 + -sisispitive K +通道不参与导管中的流动介导的扩张，并且在静息血液流动时不会在电阻容器直径维持中发挥作用。

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