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首页> 外文期刊>Alcohol >Maternal separation has no effect on voluntary ethanol intake in female Wistar rats.
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Maternal separation has no effect on voluntary ethanol intake in female Wistar rats.

机译：母体分离对雌性Wistar大鼠自愿摄入乙醇没有影响。

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摘要

Adverse experiences, early in life or during adulthood, can increase the vulnerability for development of drug dependence. Investigators have shown that short and prolonged periods of maternal separation during the postnatal period can affect voluntary ethanol intake in male rats. Recent study findings have indicated sex-dependent effects of maternal separation, and, in the current study, the effects of maternal separation on acquisition of voluntary ethanol intake in female Wistar rats were investigated. Rat pups were subjected to daily maternal separation for 15 min (MS15) or 360 min (MS360) during the first 3 weeks of life or reared under normal animal facility rearing (AFR) conditions. During 25 days, starting at 10 weeks of age, the effects of maternal separation on acquisition of voluntary ethanol intake were investigated. In contrast with previous study results for male rats, neither MS15 nor MS360 affected acquisition of voluntary ethanol intake in female rats. A stressful situation in adulthood, restraint stress, resulted in a significant increase in ethanol intake during the restraint period compared with baseline levels in the animals reared under normal AFR conditions, an effect that persisted throughout the postrestraint period. In rats subjected to MS15 or MS360, a significant increase in ethanol intake was shown during the postrestraint period compared with baseline levels. The current study findings therefore give further evidence for sex differences in the consequences of maternal separation. Compared with previous findings in male rats, acquisition of ethanol intake was not affected, and restraint-induced effects were less pronounced but more prolonged, in female rats.
机译：生命早期或成年期间的不良经历可能会增加药物依赖性发展的脆弱性。研究人员表明，产后短期和长期母体分离会影响雄性大鼠自愿摄入乙醇。最近的研究发现表明母体分离具有性别依赖性，并且在当前研究中，研究了母体分离对雌性Wistar大鼠自愿摄取乙醇的影响。在出生后的前三周，将幼鼠每天进行母体分离15分钟（MS15）或360分钟（MS360），或在正常动物设施饲养（AFR）条件下饲养。从10周龄开始的25天内，研究了母亲分离对自愿摄入乙醇的影响。与以前的雄性大鼠研究结果相反，MS15和MS360均不影响雌性大鼠自愿摄入乙醇。与在正常AFR条件下饲养的动物的基线水平相比，成年后的紧张情况，约束压力导致约束期间乙醇摄入量显着增加，这种作用在约束后整个时期都持续存在。在接受MS15或MS360的大鼠中，与基线水平相比，约束后期间的乙醇摄入量显着增加。因此，当前的研究结果为产妇分居后果中的性别差异提供了进一步的证据。与先前在雄性大鼠中的发现相比，在雌性大鼠中乙醇摄入量的获得没有受到影响，约束诱导的作用较不明显，但延长了。

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