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首页> 外文期刊>Alcohol >Plasma homocysteine concentrations do not influence craving in alcohol withdrawal.
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Plasma homocysteine concentrations do not influence craving in alcohol withdrawal.

机译：血浆高半胱氨酸浓度不影响戒酒的渴望。

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Results of a number of studies indicate that the glutamate system, especially the N-methyl-D-aspartate (NMDA) receptor, has a major function in chronic alcoholism, including craving. Homocysteine and other excitatory amino acids, such as glutamate and aspartate, lead to an overstimulation of NMDA receptors. Because alcoholism is associated with elevated plasma homocysteine concentrations, we designed the current study to determine whether elevated plasma homocysteine concentrations have an influence on craving in alcohol withdrawal. Two groups of patients with an established diagnosis of alcohol dependence were compared. Group A comprised 50 consecutively admitted alcohol-dependent individuals who had been abstinent from alcohol between 24 and 72 h before hospitalization. Group B comprised 146 consecutively recruited alcohol-dependent individuals who were admitted, acutely intoxicated, for withdrawal treatment. All patients were assessed with the Obsessive Compulsive Drinking Scale (OCDS) on the day ofadmission and after 7 days of treatment. The mean (27.1, S.D. 18.4) plasma homocysteine concentration for group B was significantly higher than the mean (12.5, S.D. 5.3) plasma homocysteine concentration for group A (Mann-Whitney U test: P < .001). No significant influence of homocysteine concentration on the extent of craving was found for either group with the use of the Spearman correlation (day 0: group A, r = -.076, P = .601; group B, r = .120, P = .148) and logistic regression analysis. Although homocysteine is a potent modulator of glutamatergic neurotransmission, results of the current study provide no evidence for a pathophysiologic role of homocysteine in withdrawal craving. Therefore, further research about alcohol craving should focus on neurobiologic factors other than homocysteine.
机译：多项研究结果表明，谷氨酸系统，尤其是N-甲基-D-天冬氨酸（NMDA）受体，在包括渴望在内的慢性酒精中毒中起主要作用。同型半胱氨酸和其他兴奋性氨基酸（例如谷氨酸和天冬氨酸）导致NMDA受体的过度刺激。由于酒精中毒与血浆同型半胱氨酸浓度升高有关，因此我们设计了当前研究以确定血浆同型半胱氨酸浓度升高是否对戒酒的渴望产生影响。比较了确定酒精依赖的两组患者。 A组由50名连续入院的酒精依赖者组成，他们在住院前24至72小时内戒酒。 B组包括146名连续招募的酒精依赖者，他们被接受了急性中毒的戒断治疗。在入院当天和治疗7天后，对所有患者进行强迫性饮水量表（OCDS）评估。 B组的血浆同型半胱氨酸平均浓度（27.1，S.D. 18.4）明显高于A组的平均血浆同型半胱氨酸浓度（12.5，S.D. 5.3）（Mann-Whitney U检验：P <.001）。使用Spearman相关性，两组中的同型半胱氨酸浓度对渴望程度均无显着影响（第0天：A组，r = -.076，P = .601; B组，r = .120，P = .148）和逻辑回归分析。尽管高半胱氨酸是谷氨酸能神经传递的有效调节剂，但目前的研究结果并未提供高半胱氨酸在戒断渴望中的病理生理作用的证据。因此，关于饮酒的进一步研究应集中于同型半胱氨酸以外的神经生物学因素。

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